The ripple effect of a complication in lung transplantation: Evidence for increased long-term survival risk

The Journal of Thoracic and Cardiovascular Surgery
Ernest G ChanJonathan D'Cunha

Abstract

Lung transplantation is a life-saving procedure for patients who have end-stage lung disease. The frequency and severity of complications have not been fully characterized. We hypothesized that early in-hospital, postoperative complications decrease long-term survival. We retrospectively identified in-hospital complications in lung transplant recipients, from the period January 2007 to October 2013. Complications were graded using the extended Accordion Severity Grading System (ASGS). Complications were categorized by event and organ system. Survival analysis was performed (P < .05) using a time-dependent model. Among 748 eligible patients, 3381 independent in-hospital, postoperative complications occurred in 92.78% of patients. Median follow-up was 5.4 years. Complications associated with significant decrease in 5-year survival were: renal (hazard ratio [HR] 2.58, 95% confidence interval [CI] 1.40-4.48); hepatic (HR 4.08, 95% CI 2.86-5.82); cardiac (HR 1.95, 95% CI 1.56-2.45). The maximum ASGS of ≥5 (18.5% vs 73.8%), and the weighted ASGS sum >10 (2.5% vs 73.8%), were found to be significant predictors of long-term survival. Multivariate analysis identified a weighted ASGS sum of >10, and renal, cardiac, and vascular complicat...Continue Reading

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Citations

Feb 22, 2017·Seminars in Cardiothoracic and Vascular Anesthesia·Kathirvel Subramaniam, Soheyla Nazarnia
Jan 20, 2018·Clinical Transplantation·Nicholas R HessJonathan D'Cunha
Jan 3, 2020·Journal of Palliative Medicine·Eric NolleyYael Schenker
May 8, 2021·Clinical Transplantation·Eric J HyznyPablo G Sanchez

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