The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis

Arthritis and Rheumatism
J F FriesBonnie Bruce

Abstract

Nonsteroidal antiinflammatory drug (NSAID)-associated gastropathy is a major cause of hospitalization and death. This study was undertaken to examine whether recent preventive approaches have been associated with a declining incidence of NSAID gastropathy, and, if so, what measures may have caused the decline. We studied 5,598 patients with rheumatoid arthritis (RA) over 31,262 patient-years at 8 sites. We obtained standardized longitudinal information on the patients that had been previously used to establish the incidence of NSAID gastropathy, and also information on patient risk factors and differences in toxicity between NSAIDs. Consecutive patients were followed up with biannual Health Assessment Questionnaires and medical record audits between 1981 and 2000. The major outcome measure was the annual rate of hospitalization involving bleeding, obstruction, or perforation of the gastrointestinal (GI) tract and related conditions. Rates of GI-related hospitalizations rose from 0.6% in 1981 to 1.5% in 1992 (P < 0.001), and then declined to 0.5% in 2000 (P < 0.001). The fitted spline curve fit the data well (R2 = 0.70). The period of rise was mainly associated with increasing patient age and the GI risk propensity score. The pe...Continue Reading

References

Sep 1, 1991·The American Journal of Medicine·J F FriesB A Michel
Nov 1, 1991·Arthritis and Rheumatism·J F FriesD A Bloch
Jun 13, 1991·The New England Journal of Medicine·P M Brooks, R O Day
Jan 1, 1990·Arthritis and Rheumatism·J F FriesH B Hubert
Sep 1, 1988·Annals of Internal Medicine·M R GriffinW Schaffner
May 1, 1974·The American Journal of Digestive Diseases·D C SunD W Englund
Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Dec 2, 1999·JAMA : the Journal of the American Medical Association·M J LangmanT J Simon
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Jan 16, 2002·Annals of Internal Medicine·UNKNOWN U.S. Preventive Services Task Force
Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
Jun 28, 2002·The New England Journal of Medicine·Kam Chuen LaiJohn Wong

❮ Previous
Next ❯

Citations

May 27, 2008·Wiener medizinische Wochenschrift·Sjef van der Linden
Jun 1, 2010·The Proceedings of the Nutrition Society·Michael JamesLes Cleland
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Eliza F Chakravarty, James F Fries
Jan 15, 2009·American Journal of Therapeutics·Arthur L Weaver
Jan 13, 2011·BMJ : British Medical Journal·Sven TrellePeter Jüni
Jan 6, 2006·The Journal of Clinical Investigation·Tilo GrosserGarret A FitzGerald
Jul 6, 2007·BMC Gastroenterology·Michael LoydPhilip Jacobs
Jan 8, 2009·Osteopathic Medicine and Primary Care·A Mark Fendrick, Bruce P Greenberg
Sep 20, 2005·Arthritis Research & Therapy·Steven B Abramson, Arthur L Weaver
Sep 20, 2005·Arthritis Research & Therapy·David A Peura, Lawrence Goldkind
Sep 20, 2005·Arthritis Research & Therapy·Jeffrey S Borer, Lee S Simon
Dec 7, 2013·Arthritis Research & Therapy·Carlos SostresAngel Lanas
Feb 6, 2009·Drugs·Marco Lazzaroni, Gabriele Bianchi Porro
Jan 16, 2016·Zeitschrift für Rheumatologie·W W BoltenUNKNOWN Kommission Pharmakotherapie der DGRh
Jul 7, 2007·Scandinavian Journal of Gastroenterology·Arja Helin-SalmivaaraRisto Huupponen
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Mansoor AhmedDaniel E Furst
Dec 6, 2011·Best Practice & Research. Clinical Rheumatology·Nicola J Gullick, David L Scott
Sep 29, 2011·Gastrointestinal Endoscopy Clinics of North America·Carlos Sostres, Angel Lanas
Mar 17, 2010·Best Practice & Research. Clinical Gastroenterology·Carlos SostresAngel Lanas
Sep 1, 2008·Reumatología clinica·Estíbaliz Loza
Dec 6, 2007·La Presse médicale·Jean SibiliaGilles Montalescot
Nov 18, 2009·British Journal of Clinical Pharmacology·Benedict W WheelerRichard M Martin
May 16, 2006·Alimentary Pharmacology & Therapeutics·P N PostG A Meijer
May 17, 2006·Alimentary Pharmacology & Therapeutics·C Scarpignato, I Pelosini
Jul 1, 2006·Chinese Journal of Digestive Diseases·Angel Lanas, Angel Ferrandez
Nov 24, 2005·Alimentary Pharmacology & Therapeutics·R H Hunt
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Theresa I Shireman, Sally K Rigler
Jun 17, 2006·Best Practice & Research. Clinical Rheumatology·Nurullah AkkocMuhammad Asim Khan
May 16, 2006·Digestive Diseases·Carmelo ScarpignatoFrancesco Di Mario
Mar 20, 2012·Biochemical and Biophysical Research Communications·Kaname OhyamaNaotaka Kuroda
Jan 13, 2006·Journal of Ethnopharmacology·Ana María PederneraLilian Eugenia Pelzer
May 7, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Andrea Sbrozzi-VanniBruno Annibale

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.