The rise of apoptosis: targeting apoptosis in hematologic malignancies.

Blood
Rebecca ValentinMatthew S Davids

Abstract

Dysregulation of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins of the intrinsic apoptotic pathway is fundamental to the pathophysiology of many hematologic malignancies. The BCL-2 family consists of regulatory proteins that either induce apoptosis (proapoptotic) or inhibit it (prosurvival). BCL-2, myeloid cell leukemia-1, and B-cell lymphoma-extra large are prosurvival proteins that are prime targets for anticancer therapy, and molecules targeting each are in various stages of preclinical and clinical development. The US Food and Drug Administration (FDA)-approved BCL-2 inhibitor venetoclax was first proven to be highly effective in chronic lymphocytic leukemia and some B-cell non-Hodgkin lymphoma subtypes. Subsequently, venetoclax was found to be active clinically against a diverse array of hematologic malignancies including multiple myeloma, acute myeloid leukemia, myelodysplastic syndrome, acute lymphoblastic leukemia, and others. Here, we give a brief introduction to BCL-2 family biology and the mechanism of action of BCL-2 Homology 3 (BH3) mimetics, and provide an overview of the clinical data for therapeutically targeting prosurvival proteins in hematologic malignancies, with a focus on BCL-2 inhibition. To pr...Continue Reading

References

Jun 21, 1985·Science·Y TsujimotoC M Croce
Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K M KozopasR W Craig
Apr 20, 1995·Nature·T ChittendenB C Guild
Nov 15, 1996·Genes & Development·K WangS J Korsmeyer
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Y HsuA J Hsueh
Feb 28, 1998·The EMBO Journal·L O'ConnorD C Huang
Feb 26, 1998·The New England Journal of Medicine·M SilvaJ L Fernández-Luna
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 23, 2001·Leukemia·P P RuvoloW S May
Jul 21, 2001·Molecular Cell·J YuB Vogelstein
Jul 21, 2001·Molecular Cell·K Nakano, K H Vousden
Dec 12, 2003·Nature·Joseph T OpfermanStanley J Korsmeyer
Apr 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Guido MarcucciJohn C Byrd
May 20, 2005·Nature·Tilman OltersdorfSaul H Rosenberg
Sep 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·Amelia CimminoCarlo M Croce
Sep 28, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan M O'BrienKanti R Rai
Jan 4, 2007·The Journal of Clinical Investigation·Victoria Del Gaizo MooreAnthony Letai
Mar 27, 2007·Cell·Kylie D MasonBenjamin T Kile
Dec 7, 2007·Blood·Victoria Del Gaizo MooreAnthony Letai
May 3, 2008·Cancer Research·Christin TseSteven W Elmore
Sep 10, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan O'BrienKanti R Rai
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jeremy A RyanAnthony Letai

❮ Previous
Next ❯

Citations

Jan 30, 2019·The Cancer Journal·Raphaël Szalat, Nikhil C Munshi
Dec 1, 2018·Journal of Cellular Physiology·Raedeh SaraeiAli Hassanzadeh
Apr 11, 2019·Expert Opinion on Drug Metabolism & Toxicology·Anna Korycka-WolowiecTadeusz Robak
Apr 3, 2019·Critical Reviews in Clinical Laboratory Sciences·Cristina BagaceanYves Renaudineau
Nov 26, 2019·The Cancer Journal·Christine E Ryan, Matthew S Davids
Mar 7, 2020·Blood·Stephen J F Chong, Matthew S Davids
Mar 7, 2020·Cancers·Natalie Yan Li NgoiShazib Pervaiz
Nov 5, 2019·Frontiers in Pediatrics·Thomas Mercher, Juerg Schwaller
Jul 28, 2020·Journal of Experimental & Clinical Cancer Research : CR·Juan YangXin Wang
Apr 27, 2020·Apoptosis : an International Journal on Programmed Cell Death·Prashanthi Ramesh, Jan Paul Medema
Aug 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Young Yun JungKwang Seok Ahn
Apr 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rania HamdyAndrew D Westwell
Dec 7, 2019·Hematology·Anjali S Advani, Edward A Copelan
Dec 2, 2020·International Journal of Molecular Sciences·Rania HamdyAndrew D Westwell
Dec 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Marc SerullaChristian Widmann
Nov 9, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin CidadoLisa Drew
Dec 15, 2020·Journal of Oncology·Omar Ugarte-AlvarezRosendo Luria-Pérez
Apr 6, 2020·The Journal of Investigative Dermatology·Johanna StroblGeorg Stary
Apr 15, 2020·Experimental Neurology·Epiphani C SimmonsRick G Schnellmann
Apr 4, 2021·International Journal of Molecular Sciences·Anna RichterChristian Junghanss
May 6, 2021·Cancers·Etienne Leveille, Nathalie A Johnson
Jun 1, 2021·Signal Transduction and Targeted Therapy·Lei ZhongShengyong Yang
Aug 19, 2021·Expert Review of Hematology·Judith S HeckerKatharina S Götze
Apr 23, 2021·Haematologica·Rebecka SvanbergCarsten U Niemann
Sep 28, 2021·Frontiers in Cell and Developmental Biology·Albert Manzano-MuñozJoan Montero

❮ Previous
Next ❯

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

© 2022 Meta ULC. All rights reserved