The Rising Phoenix-Progesterone as the Main Target of the Medical Therapy for Leiomyoma

BioMed Research International
Henry H ChillAsher Shushan

Abstract

Leiomyomas, also known as uterine fibroids, are a common benign tumor in women of reproductive age. These lesions disrupt the function of the uterus causing menorrhagia and pelvic pressure as well as reproductive disorders. These women pose a true challenge for clinicians in the attempt of choosing the suitable treatment for each patient. Patient's age, interest in fertility preservation, and leiomyoma location and size are all factors to be taken into account when deciding upon the preferable therapeutic option. For the past few decades, surgical treatment was the only reliable long-term treatment available. A variety of surgical approaches have been developed over the years but these developments have come at the expense of other treatment options. The classical medical treatment includes gonadotropin-releasing hormone (GnRH) agonists and antagonists. These agents are well known for their limited clinical effect as well as their broad spectrum of side effects, inspiring a need for new pharmacological treatments. In recent years, promising results have been reported with the use of selective progesterone receptor modulators (SPRM). Long-term clinical trials have shown a reduction in bleeding and shrinkage of leiomyoma mass. Th...Continue Reading

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Dec 14, 2019·Menopause : the Journal of the North American Menopause Society·Mara UlinQiwei Yang
Apr 30, 2020·International Journal of Molecular Sciences·Michał CiebieraArtur Czekierdowski
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Aug 25, 2018·BioMed Research International·Michał CiebieraMarta Włodarczyk
Oct 28, 2020·Reproductive Sciences·Michał CiebieraAyman Al-Hendy

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Methods Mentioned

BETA
hysterectomy
hormone replacement therapy

Software Mentioned

PREMYA

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