The risk for Chagas' disease in the Midwestern United States organ donor population is low

Clinical Transplantation
Christopher F BryanMark I Aeder

Abstract

Several recent publications have increased awareness that transplanted organs can transmit infectious diseases. In light of the recent report describing the transmission of Trypanosoma cruzi infection by an organ donor in the United States (MMWR 2002: 51: 210), we have tested archived serum samples from our Organ Procurement Organization's (OPO's) deceased organ donors and live donors from 23 October 1995 through 1 March 2002. A total of 1117 serum samples from 558 locally recovered deceased donors, 178 imported deceased donors, and 212 live donors were tested (several duplicates were included). Samples were screened for antibodies to T. cruzi, the protozoan parasite that causes Chagas' disease, with a passive particle agglutination assay (Fujirebio, Inc., Tokyo, Japan). Indeterminate samples (those agglutinating both sensitized and control particles) were absorbed with control antigen and re-tested. Inconclusive samples (those not yielding clearly negative or positive results) were re-tested using the original test format, and if persistently inconclusive, were assayed by radio-immune precipitation (RIPA). Of the 770 local OPO donors (deceased and live donor) and the 178 imported donors tested, 52 (5.5%) were indeterminate, bu...Continue Reading

References

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Citations

Aug 31, 2006·Nature Clinical Practice. Nephrology·Rashad S Barsoum
Jan 19, 2008·Clinical Microbiology Reviews·P Martín-DávilaS Moreno
Nov 26, 2010·Dermatologic Clinics·Eva Rawlings Parker, Aisha Sethi
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Aug 16, 2006·Bioorganic & Medicinal Chemistry·Lilian Sibelle Campos BernardesIvone Carvalho

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