The Risk for Lung Cancer Incidence with Calcium Channel Blockers: A Systematic Review and Meta-Analysis of Observational Studies

Drug Safety : an International Journal of Medical Toxicology and Drug Experience
Victoria RotshildIlan Matok

Abstract

There are conflicting findings regarding the association between the use of calcium channel blockers (CCBs) and the risk of lung cancer. Considering the public health importance of lung cancer prevention, and emerging evidence of a significant biologic role of calcium channel regulation in the development of lung cancer, we conducted a meta-analysis to assess the risk of lung cancer in CCB users compared with non-CCB users. We conducted a comprehensive systematic search of leading medical databases for observational studies published up to December 2017 that examined CCB use and the risk of lung cancer. We used random-effects models to pool results. The impact of duration of CCB use on the estimated effect size was explored using random effects meta-regression. Ten studies (six cohort and four case-control studies) that evaluated the overall cancer risk among 38,758 CCB users were included in the analysis. Overall risk ratio (RR) for CCB use and lung cancer was 1.15 (95% confidence interval [CI] 1.01-1.32). Subgroup analysis by duration of CCB use suggested that the observed increase in lung cancer risk was driven by the results of five studies with prolonged (≥ 4 years) exposure (RR 1.18; 95% CI 1.08-1.30). Our analysis sugges...Continue Reading

References

Apr 1, 1985·Journal of the National Cancer Institute·A H WuM C Yu
May 11, 1996·BMJ : British Medical Journal·N Black
Jul 1, 1996·American Journal of Hypertension·M PahorR J Havlik
Feb 22, 1997·Lancet·H JickC R Meier
May 1, 1997·Hypertension·J H OlsenJ Olsen
Dec 24, 1997·Hypertension·M Pahor
Apr 9, 1998·Journal of Hypertension·D J HoleA F Lever
Apr 9, 1998·JAMA : the Journal of the American Medical Association·L RosenbergS Shapiro
Dec 1, 1998·JAMA : the Journal of the American Medical Association·J Zhang, K F Yu
Jan 8, 1999·American Journal of Hypertension·R M VezinaS Shapiro
Dec 31, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A B Beiderbeck-NollB H Ch Stricker
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Spotswood L SpruanceMatthew Samore
Jan 26, 2007·Pharmacoepidemiology and Drug Safety·Samy Suissa
Dec 7, 2007·American Journal of Epidemiology·Samy Suissa
Dec 18, 2007·Annals of Epidemiology·Anil K ChaturvediEric A Engels
Sep 10, 2008·Pharmacoepidemiology and Drug Safety·Themistocles L AssimesSamy Suissa
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jan 13, 2010·Environmental Health Perspectives·Neela GuhaKurt Straif
Aug 6, 2011·Journal of Neurotrauma·Juan LuUNKNOWN IMPACT Investigators
Nov 23, 2012·Diabetes Care·Samy Suissa, Laurent Azoulay
Dec 20, 2012·PloS One·Laurent AzoulaySamy Suissa
Nov 25, 2014·European Heart Journal·Bruno R da Costa, Peter Juni
Dec 3, 2014·International Journal of Cardiology·Martin C S WongAndrew J S Coats
Sep 1, 2015·The Medical Clinics of North America·Christopher J Wong, Genevieve Pagalilauan

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Citations

May 30, 2019·The Annals of Pharmacotherapy·Victoria RotshildIlan Matok
Oct 22, 2019·International Journal of Cancer. Journal International Du Cancer·Shih-Wei LaiKuan-Fu Liao
Aug 1, 2020·Frontiers in Pharmacology·Sendoa Tajada, Carlos Villalobos
Nov 18, 2018·The Annals of Pharmacotherapy·Victoria RotshildIlan Matok
Jun 13, 2020·American Journal of Hypertension·Elias SanidasJohn Barbetseas
Jun 8, 2021·Frontiers in Oncology·José A Carlos-EscalanteTalia Wegman-Ostrosky

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