The risk of distant metastases after transurethral resection of the prostate versus needle biopsy in patients with localized prostate cancer

The Journal of Urology
R B MeachamC E Carlton

Abstract

Although transurethral resection of the prostate provides an effective treatment for obstructive voiding symptoms associated with prostate cancer, there is growing concern about the possible role of transurethral resection in the dissemination of this malignancy. To determine the effect of transurethral resection on the rate of development of distant metastasis, we analyzed a large series of patients (379) treated at our institution with definitive radiotherapy for localized prostate cancer that was diagnosed by either needle biopsy or transurethral prostatic resection. In our series the presence of lymph node metastasis was documented by pelvic lymph node dissection in all patients. An initial univariate analysis suggested that patients diagnosed by transurethral resection had distant metastases significantly more rapidly than patients diagnosed by needle biopsy. However, transurethral resection usually was performed because of the presence of obstructive voiding symptoms and such patients were much more likely to have positive lymph node dissections than patients without obstructive voiding symptoms. A proportional hazards regression analysis showed that nodal status and the degree of obstructive voiding symptoms at diagnosis...Continue Reading

References

Aug 1, 1976·The Journal of Urology·C E CarltonR Scott
Aug 1, 1989·The Journal of Urology·L A GervasiP T Scardino
Jul 1, 1987·The Journal of Urology·D F Paulson, E B Cox
Jul 1, 1985·International Journal of Radiation Oncology, Biology, Physics·G E Hanks
Nov 24, 1983·The New England Journal of Medicine·P W LavoriM Polansky
Dec 1, 1983·The New England Journal of Medicine·T C ChalmersH Smith
Jun 1, 1981·The Journal of Urology·S A KramerD F Paulson
Aug 1, 1980·The Journal of Urology·G R ProutW U Shipley
Sep 1, 1980·International Journal of Radiation Oncology, Biology, Physics·D G McGowan

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Citations

Sep 1, 1992·British Journal of Urology·N GreenH S Frey
Jan 1, 1991·Urological Research·H P Schmid
Jun 1, 1993·British Journal of Urology·F H Schröder
Oct 13, 2006·BJU International·Martin MarszalekStephan Madersbacher
May 29, 2014·Korean journal of urology·Masahito KidoShin Egawa
Nov 5, 1997·Cancer·F Abbas, P T Scardino
Jan 1, 1990·Acta Oncologica·L Denis, C Mahler
Mar 1, 1992·Human Pathology·P T ScardinoM A Hudson

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