The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study

Arthritis & Rheumatology
Milica Blagojevic-BucknallEdward Roddy

Abstract

Obstructive sleep apnea (OSA) is associated with a range of serious comorbidities. This study was undertaken to investigate whether people with OSA are more likely to develop gout, in the short and long term, compared to those without OSA. A matched retrospective cohort study was undertaken using the UK Clinical Practice Research Datalink. Individuals age ≥18 years who received a diagnosis of OSA between 1990 and 2010 were identified and matched on age, sex, and practice with up to 4 individuals without OSA; follow-up was until the end of 2015. Hazard ratios (HRs) were estimated using Cox regression adjusted for general health, lifestyle, and comorbidity characteristics. The risk of developing gout was assessed at different time points, and the body mass index (BMI) category-specific results were presented. The study sample included 15,879 patients with OSA and 63,296 without. The median follow-up was 5.8 years. We found that 4.9% of patients with OSA and 2.6% of patients without the disorder developed gout. The incidence rate per 1,000 person-years was 7.83 (95% confidence interval [95% CI] 7.29-8.40) and 4.03 (95% CI 3.84-4.23) among those with and without OSA, respectively. The adjusted HR was 1.42 (95% CI 1.29-1.56). The ri...Continue Reading

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Citations

Mar 25, 2019·Sleep & Breathing = Schlaf & Atmung·Tingting ShiYehuan Sun
Apr 27, 2020·Arthritis Research & Therapy·Caroline van DurmeFrank de Vries
Jun 17, 2020·Nature Reviews. Rheumatology·Mats DehlinEdward Roddy
Jan 7, 2021·Expert Review of Molecular Diagnostics·Sompop BencharitHarmeet Chiang
Aug 29, 2021·BMC Rheumatology·Julia New-TolleyCatherine L Hill

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