The Risk of Hemorrhagic Transformation After Thrombolysis for Acute Ischemic Stroke in Chinese Versus North Americans: A Comparative Study

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Xiaomeng XuMagdy Selim

Abstract

There is a widespread belief that Asians are more susceptible to hemorrhagic transformation (HT) after receiving recombinant tissue-type plasminogen activator (rt-PA) for acute ischemic stroke (AIS). However, this has not been examined in clinical practice. This study aims to compare the incidence of symptomatic hemorrhagic transformation (SHT) among thrombolysis-treated AIS patients in China and in the United States. We compared 212 consecutive patients receiving thrombolysis within 4.5 hours of onset ± endovascular therapy from an American (n = 86) and a Chinese Stroke Center (n = 126). SHT was defined using various definitions based on the National Institute for Neurological Disorders and Stroke Recombinant Tissue Plasminogen Activator (NINDS rt-PA) trials, European-Australian Cooperative Acute Stroke Study 2 (ECASS2), and a modified version of Safe Implementation of Thrombolysis in Stroke-Monitoring Study (mSITS-MOST) study criteria. We used Firth logistic regression to adjust for confounding variables and to identify potential predictors. American patients were older, and had higher prevalence of diabetes, hypertension, cardiac disease, and prestroke use of antithrombotics. They also had higher baseline serum glucose, shor...Continue Reading

Citations

Jun 5, 2020·Neuropsychiatric Disease and Treatment·Zheren ZhouYurong Zhang
Oct 5, 2020·Clinical Neurology and Neurosurgery·Chao XiaUNKNOWN ENCHANTED Investigators
May 22, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Oğuz ÖrenMelih Yüksel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Related Papers

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
B SilverV Hachinski
Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Opeolu AdeoyeCLEAR-ER Investigators
© 2022 Meta ULC. All rights reserved