PMID: 11328214May 1, 2001Paper

The risk of limb deficiencies and other congenital abnormalities in children exposed in utero to calcium channel blockers

Acta Obstetricia Et Gynecologica Scandinavica
H T SørensenJ Olsen

Abstract

Calcium channel blockers given to pregnant rats have shown an increased prevalence of digital and limb defects and their safety in pregnant women has thus been questioned. We examined the risk of malformations following exposure in utero to calcium channel blockers. We conducted a nationwide case-control study based on the Hungarian Case-Control Surveillance of Congenital Abnormalities and identified 22,865 cases with congenital abnormalities and 31,151 population controls during the period 1980-1996. Data on drug exposure were obtained from official questionnaires and obligatory prenatal care logbooks. Among the cases, 586 mothers (2.6%) had been exposed to calcium channel blockers during pregnancy compared with 907 controls (2.4%). The overall prevalence ratios for 17 congenital abnormalities varied between 1.1 and 1.4, and there was no significant increased risk of limb deficiencies or other congenital abnormalities. Our data did not indicate an increased prevalence of congenital abnormalities in offspring exposed to calcium channel blockers in utero.

References

Mar 1, 1997·Reproductive Toxicology·W J ScottH Bürgin

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Citations

Jun 28, 2003·Current Pain and Headache Reports·Dawn A Marcus
Mar 8, 2008·Current Treatment Options in Neurology·Jan Lewis Brandes
Jul 7, 2015·The Journal of Urology·George BaileyAmy Krambeck
Jul 1, 2008·Reproductive Toxicology·Corinna Weber-SchoendorferChristof Schaefer
Dec 11, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Martha M WerlerUNKNOWN National Birth Defects Prevention Study
Nov 15, 2001·Seminars in Perinatology·K E Economy, A Z Abuhamad
Aug 30, 2005·Obstetrics and Gynecology Clinics of North America·Adrienne Z AblesSuneet P Chauhan
May 29, 2015·American Journal of Medical Genetics. Part a·Ferenc BánhidyAndrew E Czeizel
Jun 3, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Gábor VermesNándor Ács
Apr 4, 2015·Current Hypertension Reports·L FooI B Wilkinson
Sep 28, 2018·Birth Defects Research·Sarah C FisherUNKNOWN National Birth Defects Prevention Study

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