The risk of mental disorders in patients with disorders/differences of sex differentiation/development (DSD) and Y chromosome.

Endokrynologia Polska
Katarzyna BajszczakJolanta Slowikowska-Hilczer

Abstract

Patients with disorders/differences of sex differentiation/development (DSD) are exposed to physical and mental suffering. The aim of the study was to assess the following: the mental health status and the risk of mental problems in adult DSD patients, their dependence on therapeutic procedures, and to identify groups of disorders that require particular psychological support. The study involved 59 patients with DSD (gonadal dysgenesis - GD, androgen insensitivity syndrome - AIS, 5-alpha reductase deficiency, ovotestis), and with the Y chromosome in the karyotype, aged 16-65 years. All completed the General Health Questionnaire (GHQ-28) for the assessment of their mental health status. Raw results were converted into sten scores using norms for the Polish adult population to assess the risk of mental problems. A high risk of mental problems was identified in 24% of individuals (26% men, 21% women). Women, when compared with men, displayed a significantly higher mean level of anxiety and insomnia (7.3 vs. 4.6 scores) and somatic symptoms (7.4 vs. 5.5), and worse general mental health status (25.6 vs. 18.8). The most disturbing symptoms were observed among patients with complete and partial AIS, and complete GD (general mental he...Continue Reading

Citations

Sep 20, 2020·American Journal of Medical Genetics. Part a·Mia KunitomoBeth A Pletcher
Aug 26, 2021·Curēus·Marcio José Concepción-ZavaletaFrederick Glenn Massucco Revoredo

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