The risk of neurodevelopmental disorders at age 10 years associated with blood concentrations of interleukins 4 and 10 during the first postnatal month of children born extremely preterm

Cytokine
Alan LevitonOlaf Dammann

Abstract

Interleukin (IL)-4 and IL-10 are viewed mainly as anti-inflammatory cytokines. Yet, high concentrations have also been associated with inflammation-related diseases in newborns. We measured the concentrations of IL-4 and IL-10, as well as IL-8 and ICAM-1 in blood specimens collected on postnatal day 21 (N = 555), day 28 (N = 521), and both days 21 and 28 (N = 449) from children born extremely preterm (EP) (<28 weeks gestation) who at age 10 years had a DAS-II IQ Z-score > -2 (which approximates a score of >70) and the following assessments, CCC-2, and CSI-4, DAS-II, NEPSY-II, OWLS-II, SCQ, and WIAT-III. Selected children also were assessed with the ADI-R and the ADOS-2. We modeled the risk of low scores or dysfunctions associated with top quartile concentrations of IL-4 and IL-10 on each day and on both days. The risks of low scores on the Animal Sorting and Arrows components of the NEPSY-II, both components of the OWLS-II, and the PseudoWord and Spelling components of the WIAT-III were heightened among children who had top quartile concentrations of IL-4 on postnatal days 21 and 28. Children who had high concentrations of IL-10 on days 21 and 28, individually and collectively, were at increased risk of low scores on the WIAT-I...Continue Reading

Citations

Oct 28, 2018·Pediatric Research·Ivo BendixUrsula Felderhoff-Müser
May 30, 2020·Journal of Neuroinflammation·Clémence DisdierBarbara S Stonestreet
Nov 18, 2018·Pediatric Research·Cindy BokobzaPierre Gressens
Dec 17, 2019·Journal of Neurodevelopmental Disorders·Stephanie N Del TufoLaurie E Cutting
Dec 9, 2020·Pediatric Research·Imran N MirLina F Chalak

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