PMID: 9191904May 1, 1997Paper

The risk of non-melanoma skin cancer incidence in the Japanese atomic bomb survivors

International Journal of Radiation Biology
M P Little, M W Charles

Abstract

The latest Japanese atomic bomb survivor non-melanoma skin cancer incidence dataset is analysed and indicates substantial curvilinearity in the dose-response curve, consistent with a possible dose threshold of about 1 Sv, or with a dose-response in which the excess relative risk is proportional to the fourth power of dose, with a turning-over in the dose-response at high doses (> 3 Sv). The time distribution of the radiation-induced excess risk is best described by a model in which the relative excess risk is proportional to a product of powers of time since exposure and attained age. The fits of generalized relative risk models with exponential functions of time and age at exposure (and in particular of attained age) to adjust the relative risk are less satisfactory, as also are the fits of other models in which products of powers of time since exposure, age at exposure and attained age adjust the excess absolute risk. Sensitivity analyses indicate the importance of likely adjustments to the Hiroshima neutron doses for the optimal model parameters, particularly if values of the neutron relative biological effectiveness (RBE) of more than 5 are assumed. If adjustments recently proposed are made to the Hiroshima neutron doses, t...Continue Reading

References

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Mar 1, 1954·British Journal of Cancer·P ARMITAGE, R DOLL

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Citations

Oct 3, 2002·Japanese Journal of Cancer Research : Gann·Tomonori MiyazawaRyo Kominami
Feb 6, 2004·British Medical Bulletin·M P Little
Aug 24, 2004·Oncogene·Richard Wakeford
Sep 5, 2007·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·M W Charles
Sep 5, 2007·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·M W Charles
Jan 9, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Matthew D SmythPaul A Grabb
Jan 28, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Nezahat Hunter, Monty W Charles
Jan 8, 2015·Physics in Medicine and Biology·Harrison H BarrettMark P Little
Jan 28, 2003·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Nezahat Hunter, Monty W Charles
Mar 11, 2016·Annals of the ICRP·W RühmG E Woloschak
May 21, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·M P Little

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