The risk of osteopenia in premenopausal women with various sellar tumors

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Yongbo ZhaoZhou Fei

Abstract

Patients with prolactinoma seem to be at high risk for osteopenia. However, whether patients with various pathological sellar tumors have risk for osteopenia remains unclear. The aim of the present study is to assess the bone mass alteration in patients with various sellar tumors and further to investigate the risk factors of bone mass alteration. 65 premenopausal female patients with diverse sellar tumors and 325 normal controls were enrolled in this study. Bone mineral density (BMD) of lumbar spine and comprehensive endocrinological evaluations were undergone. Compared to the matched controls, BMD of patients with prolactinoma or craniopharyngioma significantly decreased. Patients with sellar meningioma and nonfunctioning adenoma are with a decreasing tendency and patients with growth hormone-secreting adenoma are with an increasing tendency compared to controls. Univariate and multivariate regression analysis indicated that the bone loss in prolactinomas was significantly correlated to disease duration and hypogonadism. In the premenopausal women, patients with prolactinoma or craniopharyngioma are often accompanied with osteopenia or osteoporosis, and disease duration and hypogonadism are the risk factors of bone loss in pr...Continue Reading

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Citations

Apr 16, 2015·International Journal of Endocrinology·Marek BolanowskiAleksandra Jawiarczyk-Przybyłowska
Nov 28, 2017·Endocrine·Deirdre Cocks EschlerEliza B Geer
Mar 8, 2020·The Journal of Clinical Endocrinology and Metabolism·Selveta S van SantenSebastian J C M M Neggers
Mar 19, 2020·The Annals of Pharmacotherapy·Satoshi YokoyamaMitsutaka Takada

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