The risk of preterm birth of treated versus untreated cervical intraepithelial neoplasia (CIN): a systematic review and meta-analysis

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nora A DanhofBen W J Mol

Abstract

Cervical surgery is associated with preterm birth (PTB) and neonatal morbidity. However, it is unknown whether this increased risk is due to the surgery itself or to the cervical intraepithelial neoplasia (CIN) underlying the surgery. Our objective was to assess the risk for PTB in women with treated and untreated CIN. We performed an electronic literature search in MEDLINE, Embase and CENTRAL for studies that reported on pregnancy outcome after treated and untreated CIN. The methodological quality was scored using the STROBE combined checklist for observational studies. We extracted data on PTB<37 weeks, very PTB<32 weeks, spontaneous PTB<37 weeks, (preterm) premature rupture of membranes ((P)PROM), perinatal mortality and section caesarean each before and after treatment for CIN. We used the Mantel-Haenszel method to estimate summarizing odds ratios. Our search identified 620 studies, of which 20 were reporting on pregnancy outcome for a total of 12,159,293 women. There were 20,832 women who gave birth after treatment for CIN before pregnancy, 52 women who gave birth after treatment for CIN during pregnancy, 64,237 women with CIN who gave birth before treatment, and 8,902,865 women who gave birth without CIN. Compared to wome...Continue Reading

References

Mar 1, 1991·Geburtshilfe und Frauenheilkunde·A RosenS Romig
Jan 1, 1982·Acta Obstetricia Et Gynecologica Scandinavica·G LarssonS Svennerud
Jan 1, 1995·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P SagotG Boog
Nov 1, 1993·Acta Obstetricia Et Gynecologica Scandinavica·J KristensenJ E Bock
Aug 1, 1997·Diagnostic Cytopathology·C W Michael, F M Esfahani
Feb 5, 1999·Obstetrics and Gynecology·A Y El-BastawissiJ R Daling
May 18, 2000·The New England Journal of Medicine·R L GoldenbergW W Andrews
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
May 6, 2004·JAMA : the Journal of the American Medical Association·Lynn SadlerLesley McCowan
Jul 20, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Merete HeinJesper Reinholdt
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Amy Berrington de GonzálezUNKNOWN International Collaboration of Epidemiological Studies of Cervical Cancer
Feb 3, 2007·Obstetrics and Gynecology·Katherine P Himes, Hyagriv N Simhan
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Sep 20, 2008·BMJ : British Medical Journal·Susanne AlbrechtsenOle Erik Iversen
Aug 25, 2009·Obstetrics and Gynecology·Maija JakobssonAnna-Maija Tapper
Nov 6, 2009·Obstetrics and Gynecology·Smruta ShanbhagMargaret Cruickshank
Dec 1, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·G OrtoftLk Petersen
Feb 24, 2010·Obstetrics and Gynecology·Claudia L WernerKenneth J Leveno
Apr 16, 2010·Journal of Women's Health·Gina M Mantia SmaldoneElizabeth A McGee
Apr 1, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·F J Bruinsma, M A Quinn
Jul 16, 2011·American Journal of Clinical Pathology·Zhuang ZuoJ Elliot Carter
Jul 25, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jelle M SchaafAmeen Abu-Hanna
Jun 12, 2013·Srpski arhiv za celokupno lekarstvo·Dragisa SljivancaninJelena Dotlić
Aug 13, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Ilenia FollettiAndrea Siracusa
Oct 15, 2013·Paediatric and Perinatal Epidemiology·Nils-Halvdan MorkenBo Jacobsson
Nov 10, 2013·Obstetrics and Gynecology·Shayna N ConnerGeorge A Macones
Mar 26, 2014·Human Reproduction Update·Annemieke KasiusFrank J M Broekmans
May 3, 2014·Obstetrics and Gynecology·Shayna N ConnerMethodius G Tuuli

❮ Previous
Next ❯

Citations

Feb 26, 2016·Seminars in Fetal & Neonatal Medicine·B KoullaliE Pajkrt
Apr 3, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ali AyhanPolat Dursun
Nov 3, 2017·The Cochrane Database of Systematic Reviews·Maria KyrgiouEvangelos Paraskevaidis
Oct 3, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Christine ColieSeble G Kassaye
Apr 12, 2019·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Joan T PriceJeffrey S A Stringer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.