The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children's Study

Reproductive Biology and Endocrinology : RB&E
Hiromitsu HattoriJapan Environment and Children’s Study Group

Abstract

Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. The Japan Environment and Children's Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage em...Continue Reading

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Citations

Mar 4, 2020·Upsala Journal of Medical Sciences·Ulla-Britt Wennerholm, Christina Bergh
Jun 12, 2021·The Journal of Investigative Dermatology·Megumi MizawaUNKNOWN Japan Environment and Children’s Study Group
Aug 17, 2021·Journal of Assisted Reproduction and Genetics·Enver Kerem Dirican, Safak Olgan
Sep 7, 2021·Archives of Gynecology and Obstetrics·Enver Kerem DiricanMete Caglar

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