The Risk of Serious Bacterial Infection in Febrile Infants 0-90 Days of Life with a Respiratory Viral Infection

The Pediatric Infectious Disease Journal
Erin G NicholsonPedro A Piedra

Abstract

Molecular diagnostic methods enhance the sensitivity and broaden the spectrum of detectable respiratory viruses in febrile infants ≤90 days of life. We describe the occurrence of respiratory viruses in this population as well as the rates of serious bacterial infection (SBI) and respiratory viral co-infection with regard to viral characteristics. This was a prospective observational cohort study performed in the emergency department that included previously healthy febrile infants ≤90 days of life. Clinical and historical characteristics were documented and a respiratory nasal wash specimen was obtained from each patient. This sample was tested for 17 common respiratory pathogens and a chart review was conducted to ascertain if the infant was diagnosed with an SBI. In a 12-month period, 67% of the 104 recruited febrile infants were positive for a respiratory virus. The most commonly detected viruses were rhinovirus, respiratory syncytial virus, enterovirus and influenza. The rate of respiratory viral and SBI co-infection was 9% overall and infants with either a systemic respiratory virus or negative viral testing were 3 times more likely to have an SBI than those with viruses typically restricted to the respiratory mucosa (95% ...Continue Reading

References

Jun 3, 2004·Pediatrics·Deborah A LevineUNKNOWN Multicenter RSV-SBI Study Group of the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy
Apr 17, 2007·The Journal of Infectious Diseases·Berkeley L BennettPedro A Piedra
Jul 1, 2009·Pediatrics·William I KriefUNKNOWN Multicenter RSV-SBI Study Group of the Pediatric Emergency Medicine Collaborative Research Committee of the American Academy
Aug 8, 2012·Pediatrics·Jonathan M MansbachUNKNOWN MARC-30 Investigators
Oct 1, 2014·Pediatrics·Paul L AronsonUNKNOWN Febrile Young Infant Research Collaborative
Nov 12, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cristina CalvoMaría Cabrerizo
Jan 19, 2018·Pediatrics·Anne J BlaschkeCarrie L Byington

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Citations

Apr 18, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michal ParetAdam J Ratner

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