The Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors.

Transplantation
Robert C WilliamsHarini A Chakkera

Abstract

Since the beginning of the technology, there has been active debate about the role of human leucocyte antigen (HLA) matching in kidney allograft survival. Recent studies have reported diminishing importance of HLA matching, which have, in turn, been challenged by reports that suggest the continuing importance of these loci. Given the controversies, we examined the effect of HLA compatibility on kidney allograft survival by studying all first adult kidney transplants in the United States from a deceased donor. Using the United Network for Organ Sharing data, we identified first deceased donor kidney transplants between October 1, 1987, and December 31, 2013. Recipients were classified by their number of HLA mismatches. Cox multivariate regression analyses adjusting for recipient and donor transplant characteristics were performed to determine the impact of HLA compatibility on kidney allograft survival. Study cohort included 189 141 first adult kidney alone transplants, with a total of 994 558 years of kidney allograft follow-up time. Analyses adjusted for recipient and donor characteristics demonstrated a 13% higher risk (hazard ratio, 1.13; 95% confidence interval, 1.06-1.21) with 1 mismatch and a 64% higher risk (hazard ratio...Continue Reading

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Citations

Feb 24, 2016·Transplantation·J Michael Cecka
Jul 12, 2016·Transplantation·Geir MjoenDag Olav Dahle
Aug 2, 2016·Transplantation·Robert C WilliamsHarini A Chakkera
Oct 16, 2016·Advances in Chronic Kidney Disease·Jeffrey MaKathryn Tinckam
Nov 9, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jeremy R Chapman
Jan 5, 2018·Interactive Cardiovascular and Thoracic Surgery·Yoshito YamadaWolfgang Jungraithmayr
Apr 24, 2018·Current Opinion in Organ Transplantation·Alyssa WardJedediah K Lewis
Aug 9, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Goran B Klintmalm, Bruce Kaplan
Jan 10, 2018·World Journal of Transplantation·Mohammed Mahdi AlthafAhmed Mostafa Halawa
Jul 10, 2018·Nature Reviews. Nephrology·Robert A MontgomeryAndrea A Zachary
Nov 11, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chris WiebePeter W Nickerson
Dec 27, 2018·The New England Journal of Medicine·Carmen Lefaucheur, Alexandre Loupy
Apr 25, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Caner Süsal, Martin Zeier
Apr 25, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Napat LeeaphornFrancesca Cardarelli
Dec 12, 2018·Nephrology·Darren LeeWilliam R Mulley
Jul 25, 2019·Nephrology·William R MulleyRhonda F Holdsworth
Dec 4, 2019·Current Opinion in Organ Transplantation·Chris Wiebe, Peter W Nickerson
Nov 17, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Rabea HeinReinhard Schwinzer
Dec 24, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Liping ChenYudi Wang
Jul 27, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Amanda J Vinson, Karthik K Tennankore
Apr 28, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Aleksandar SenevMaarten Naesens
Feb 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xian-Ding WangTao Lin
Jul 7, 2020·The Journal of Veterinary Medical Science·Keita SatoTadaaki Moritomo
Jun 1, 2018·Journal of Transplantation·Maria Cristina Ribeiro de CastroElias David-Neto
Jan 24, 2020·HLA : Immune Response Genetics·Carolyn K HurleyJason Dehn
Apr 2, 2020·Canadian Journal of Kidney Health and Disease·Timothy CaulfieldPaul Keown
Sep 19, 2020·International Journal of Immunogenetics·Fabian EchterdiekCaner Süsal
Dec 21, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Matthew P SypekJoshua Y Kausman
Mar 14, 2017·Journal of Immunology Research·Kirsten GeneugelijkEric Spierings
Dec 9, 2017·HLA : Immune Response Genetics·C UnterrainerC Süsal
May 23, 2018·Current Opinion in Organ Transplantation·Chris Wiebe, Peter Nickerson
Dec 13, 2019·Frontiers in Immunology·Fabian EchterdiekCaner Süsal
Feb 18, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ankit SharmaGermaine Wong
Sep 19, 2017·Clinical Transplantation·Mohamad M AlkadiThangamani Muthukumar
Jun 12, 2019·International Journal of Immunogenetics·B Sean CareyAnthony Poles
Nov 17, 2020·Frontiers in Immunology·Dulat BekbolsynovStanislaw M Stepkowski

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