The risk of venous thromboembolism with aspirin compared to anticoagulants after hip and knee arthroplasty

Thrombosis Research
Janet N ChuMargaret C Fang

Abstract

Recent guidelines include aspirin as an option to prevent venous thromboembolism (VTE) in selected patients undergoing hip or knee replacement surgery. However, the efficacy of aspirin after arthroplasty has not been well-defined, particularly in more contemporary patient populations. We compared rates of post-operative VTE between patients who received aspirin-only versus anticoagulants after hip or knee arthroplasty, using data from a large US-based administrative database. We conducted a retrospective cohort study of 231,780 adults who underwent total knee arthroplasty and 110,621 who underwent total hip arthroplasty in 2009-2012 and who received pharmacologic VTE prophylaxis (aspirin or anticoagulant) within the first 7days after surgery. We compared the risk of post-operative VTE between patients receiving aspirin-only vs. anticoagulants, controlling for clinical and hospital characteristics using multivariable logistic regression with propensity score adjustment. Aspirin-only prophylaxis was administered to 7.5% of patients after knee arthroplasty and 8.0% after hip arthroplasty. Post-operative VTE was diagnosed in 2217 (0.96%) patients after knee arthroplasty and 454 (0.41%) after hip arthroplasty. Compared to anticoagul...Continue Reading

Citations

Apr 17, 2019·Hip International : the Journal of Clinical and Experimental Research on Hip Pathology and Therapy·Abiram BalaDerek F Amanatullah
Feb 17, 2021·The Journal of Arthroplasty·Stefano R MuscatelliBrian R Hallstrom

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