Abstract
Interpreting the results and practice implications of clinical studies requires accurate characterisation of the baseline risk of the population. We evaluated the Thrombolysis in Myocardial Infarction (TIMI) risk score for STEMI as a tool to describe and compare the risk profile of populations enrolled in three clinical trials (InTIME-II, ASSENT-2 and MAGIC) and the National Registry of Myocardial Infarction. The risk score was calculated for each patient (N=121,085) and the frequency distribution plotted for each population. The Risk Score Profiles were compared using the Kolmogorov-Smirnov test. The Risk Score Profile demonstrated a striking concordance between the baseline risk of patients in InTIME-II and ASSENT-2 (median scores in each= 3[1,4], P=0.11). In contrast, the distributions in MAGIC (designed to enroll high risk) and NRMI (registry) were shifted significantly toward higher risk (median scores=4[3,5] for MAGIC and 4[2,6] in NRMI, P < 0.0001 for each vs. InTIME-II). A graded relationship between the risk score and mortality was evident in each study (P<0.0001). The frequency distribution of the TIMI Risk Score, or similar tools for risk assessment, may be used to quantify and readily compare the risk profile of pop...Continue Reading
Citations
Aug 18, 2005·Annales de cardiologie et d'angéiologie·J Abou TamY Cottin
Jan 25, 2007·The Canadian Journal of Cardiology·Pamela J BradshawJack V Tu
Apr 30, 2014·Mediators of Inflammation·Ying HeBaoqing Sun
Oct 10, 2007·Acute Cardiac Care·Anne VorlatChristiaan Vrints
Jan 24, 2012·Contemporary Clinical Trials·Fabrizio D'AscenzoFiorenzo Gaita
Apr 15, 2008·The Veterinary Clinics of North America. Exotic Animal Practice·Kevin T Fitzgerald, Kristin L Newquist
May 8, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Agnieszka M KuklinskaMaciej Szmitkowski
Nov 5, 2008·Annales de cardiologie et d'angéiologie·M FayardA Dellinger
Apr 23, 2005·American Heart Journal·Elliott M AntmanUNKNOWN ExTRACT-TIMI 25 Investigators
Sep 6, 2005·Journal of the American College of Cardiology·Robert P Giugliano, Eugene Braunwald
Apr 25, 2006·Journal of the American College of Cardiology·Stephen D WiviottUNKNOWN National Registry of Myocardial Infarction
Jun 10, 2009·Journal of Cardiovascular Medicine·Guglielmo BernardiUNKNOWN Working Group of Area Vasta Udinese
Sep 24, 2008·Circulation·Joseph S Alpert
Feb 3, 2007·International Heart Journal·Agnieszka M KuklinskaMalgorzata A Knapp
Jul 9, 2005·Journal of Hypertension·Giuseppe ManciaUNKNOWN ForLife study group