PMID: 6113730Jan 1, 1981Paper

The risks of long-term neuroleptic treatment of schizophrenia: especially depression and akinesia

Acta Psychiatrica Scandinavica. Supplementum
A Rifkin

Abstract

Most extrapyramidal side effects of neuroleptics are easily recognized and cause little problem in diagnosis and treatment. The exceptions are those which mimic psychopathology: akathesia and akinesia. Akathesia resembles anxiety. Akinesia is similar to depression, residual schizophrenia, and demoralization. Differential diagnosis may require interruption of the neuroleptic. Whether neuroleptics can cause depression not associated with akinesia has never been established. The first obligation of the clinician is to be sure that the depressive symptoms are not concomitants of akinesia, before treating with antidepressants which may not be the appropriate treatment. There is no convincing evidence that one neuroleptic drug is more likely to cause akinesia than another, although this had not been studied extensively using a broad definition of akinesia.

References

Apr 1, 1978·Archives of General Psychiatry·A RifkinD F Klein
Jan 1, 1974·The American Journal of Psychiatry·C P ChienJ O Cole
Jan 1, 1970·Acta Psychiatrica Scandinavica. Supplementum·G M Simpson, J W Angus

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Citations

Aug 1, 1983·Brain Research Bulletin·C Y Yung
Dec 1, 1989·The Australian and New Zealand Journal of Psychiatry·H A Whiteford, C A Peabody
Oct 7, 2010·The Journal of Clinical Psychiatry·John M Kane, Christoph U Correll
Nov 1, 1990·The International Journal of Neuroscience·R Sandyk, S R Kay
Dec 7, 2007·Schizophrenia Research·Massimo C MauriAlessandro Colasanti
Sep 24, 2005·Comprehensive Psychiatry·Paola RoccaFilippo Bogetto
Aug 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·D A Johnson
Aug 1, 1990·The International Journal of Neuroscience·R Sandyk, S R Kay

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