The risks of PPI therapy.

Nature Reviews. Gastroenterology & Hepatology
Paul Moayyedi, Grigorios I Leontiadis

Abstract

PPIs have become one of the most commonly used medications worldwide, as they are the treatment of choice for several acid-related gastrointestinal disorders. However, concerns have been raised about PPI therapy, including the risk of pneumonia, bone fractures and enteric infections, and a possible interaction with clopidogrel that could increase the risk of cardiovascular events. Observational studies have shown very modest associations between PPI therapy and these risks, although the association between PPI treatment and the risk of enteric infections seems to be stronger than the association with other risk factors. However, given the inherent limitations of observational studies, these associations could be attributable to bias and/or confounding factors. In addition, evidence from randomized, controlled trials does not support a clinically significant effect of PPI therapy on the risk of cardiovascular events in patients taking clopidogrel or the risk of pneumonia. Nevertheless, it is impossible to exclude the possibility that some of these associations might be causal or indeed that PPI therapy has an as yet unknown long-term adverse effect. As with any therapy, therefore, it is advisable to prescribe PPIs only to patien...Continue Reading

References

May 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J B GoerssL J Melton
Feb 1, 1980·The American Journal of Medicine·R I Horwitz, A R Feinstein
Aug 6, 1998·Alimentary Pharmacology & Therapeutics·S P PereiraR H Dowling
Sep 22, 1998·Journal of Nutritional Science and Vitaminology·O ChonanM Watanuki
Oct 28, 2004·JAMA : the Journal of the American Medical Association·Robert J F LaheijJan B M J Jansen
Jul 2, 2005·The American Journal of Medicine·Mary Beth O'ConnellLawrence J Kerzner
Jul 27, 2005·Alimentary Pharmacology & Therapeutics·P Moayyedi, A T R Axon
Jan 18, 2006·JAMA : the Journal of the American Medical Association·Sandra DialSamy Suissa
Jun 27, 2006·Lancet·Paul Moayyedi, Nicholas J Talley
Dec 13, 2006·Archives of Internal Medicine·Sophia V KazakovaL Clifford McDonald
Dec 28, 2006·JAMA : the Journal of the American Medical Association·Yu-Xiao YangDavid C Metz
May 19, 2007·The American Journal of Gastroenterology·Jennifer LeonardPaul Moayyedi
Jun 19, 2008·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lennart Estborn, Svante Joelson
Aug 13, 2008·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Laura E TargownikWilliam D Leslie
Sep 17, 2008·Annals of Internal Medicine·Monika SarkarYu-Xiao Yang
Sep 25, 2008·Calcified Tissue International·Elaine W YuDouglas C Bauer
Sep 27, 2008·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Nabil SultanJames Gregor
Oct 16, 2008·The American Journal of Gastroenterology·Paul Moayyedi, Ann Cranney
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Nov 18, 2008·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Paul Moayyedi, UNKNOWN CAG Clinical Affairs Committee
Nov 22, 2008·Calcified Tissue International·Christian RouxClaus C Glüer
Dec 5, 2008·Alimentary Pharmacology & Therapeutics·A RostomUNKNOWN Canadian Association of Gastroenterology Consensus Group
Dec 18, 2008·The American Journal of Gastroenterology·Paul Moayyedi
Jan 30, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·David N JuurlinkMuhammad M Mamdani
Mar 5, 2009·JAMA : the Journal of the American Medical Association·P Michael HoJohn S Rumsfeld
Mar 6, 2009·The American Journal of Gastroenterology·M Sandra Dial
Mar 6, 2009·The American Journal of Gastroenterology·Nimish Vakil
Mar 6, 2009·The American Journal of Gastroenterology·Joel J HeidelbaughJohn M Inadomi
Apr 1, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F de VriesC Cooper
Apr 18, 2009·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Paul Moayyedi, Daniel C Sadowski
May 28, 2009·JAMA : the Journal of the American Medical Association·Shoshana J HerzigEdward R Marcantonio
Aug 21, 2009·Alimentary Pharmacology & Therapeutics·W C GallahanR S Bloomfeld
Oct 3, 2009·Epidemiology·Luis Alberto García RodríguezSaga Johansson
Nov 12, 2009·The American Journal of Gastroenterology·Loren Laine, Charles Hennekens
Feb 26, 2010·Pharmacotherapy·Tina J Liu, Cynthia A Jackevicius
Mar 13, 2010·Alimentary Pharmacology & Therapeutics·J JohnstoneM Loeb
Mar 25, 2010·The American Journal of Gastroenterology·Anna NiklassonEinar Björnsson

❮ Previous
Next ❯

Citations

Oct 11, 2014·Pharmacogenomics·John J Lima, James P Franciosi
Sep 7, 2014·Family Practice·Peter HaastrupDorte E Jarbøl
Sep 4, 2013·Best Practice & Research. Clinical Gastroenterology·Philip WoodlandDaniel Sifrim
Jun 3, 2014·Expert Opinion on Drug Metabolism & Toxicology·Yan SunRichard W McCallum
Sep 26, 2015·Journal of the Chinese Medical Association : JCMA·Bo-Lung HoShen-Shong Chang
Jun 25, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stephanie MedlockAmeen Abu-Hanna
Jan 19, 2016·Expert Review of Gastroenterology & Hepatology·Luigi MelcarneXavier Calvet
Apr 2, 2016·Research in Social & Administrative Pharmacy : RSAP·Pratik P RaneRajender R Aparasu
Aug 1, 2014·Alimentary Pharmacology & Therapeutics·J SteinR Weiner
Sep 30, 2015·Journal of the American Geriatrics Society·Andrew M HinsonDonald L Bodenner
Aug 8, 2015·International Journal of Family Medicine·Jon Eik ZwislerOve B Schaffalitzky de Muckadell
May 2, 2014·The European Journal of General Practice·Peter HaastrupDorte Ejg Jarbøl
Apr 7, 2016·The Lancet. Respiratory Medicine·Steven D Nathan
May 27, 2016·Journal of the American Geriatrics Society·Andrew M HinsonDonald L Bodenner
Aug 12, 2014·Expert Review of Anti-infective Therapy·Angela VassalloEllie J C Goldstein
Sep 14, 2013·The Annals of Otology, Rhinology, and Laryngology·Suzanne KirchAdam D Rubin
Jun 21, 2017·The American Journal of Gastroenterology·Paul M MoayyediNimish Vakil
Dec 8, 2017·The American Journal of Gastroenterology·Paul Moayyedi, Maxine A Lewis
Oct 30, 2015·Clinical and Translational Gastroenterology·Richard H Hunt, Carmelo Scarpignato
Jun 14, 2013·The Cochrane Database of Systematic Reviews·Ignacio NeumannGrigorios I Leontiadis
Nov 7, 2013·The American Journal of Gastroenterology·Grigorios I Leontiadis
Jan 30, 2013·Nature Reviews. Gastroenterology & Hepatology·Hidekazu Suzuki, Paul Moayyedi
Jul 6, 2012·The American Journal of Gastroenterology·Grigorios I LeontiadisColin W Howden
Jun 5, 2014·The American Journal of Gastroenterology·Imran SheikhM Michael Wolfe
Oct 21, 2017·Nature Reviews. Disease Primers·Fernando J MartinezAthol U Wells
Sep 12, 2014·Current Treatment Options in Gastroenterology·Grigorios I Leontiadis, Paul Moayyedi
Jul 30, 2019·Journal of Clinical Gastroenterology·Evan WiensLaura E Targownik
Apr 25, 2015·American Journal of Physiology. Gastrointestinal and Liver Physiology·P WoodlandD Sifrim
Aug 29, 2019·Arquivos De Gastroenterologia·Schlioma ZaterkaDecio Chinzon
Aug 18, 2017·Nature Communications·Berta Esteban-Fernández de ÁvilaJoseph Wang
Dec 7, 2019·Current Gastroenterology Reports·Takeshi Kanno, Paul Moayyedi
Sep 10, 2019·Expert Opinion on Drug Safety·Aitor Lanas-GimenoÁngel Lanas
Jul 15, 2018·Gut·Paul MoayyediGrigorios I Leontiadis
Jun 22, 2013·Journal of Clinical Gastroenterology·Philip Woodland, Daniel Sifrim
Sep 8, 2020·Expert Opinion on Pharmacotherapy·Nicolas ChapelleMarc Bardou
Jan 1, 2014·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Noriaki ManabeKen Haruma

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.