PMID: 8982015Jan 1, 1997Paper

The RNA-binding protein HF-I plays a global regulatory role which is largely, but not exclusively, due to its role in expression of the sigmaS subunit of RNA polymerase in Escherichia coli

Journal of Bacteriology
A MufflerR Hengge-Aronis

Abstract

The hfq-encoded RNA-binding protein HF-I has long been known as a host factor for phage Qbeta RNA replication and has recently been shown to be essential for translation of rpoS, which encodes the sigmaS subunit of RNA polymerase. Here we demonstrate that an hfq null mutant does not synthesize glycogen, is starvation and multiple stress sensitive, and exhibits strongly reduced expression of representative sigmaS-regulated genes. These phenotypes are consistent with strongly reduced sigmaS levels in the hfq mutant. However, the analysis of global protein synthesis patterns on two-dimensional O'Farrell gels indicates that approximately 40% of the more than 30 proteins whose syntheses are altered in the hfq null mutant are not affected by an rpoS mutation. We conclude that HF-I is a global regulator involved in the regulation of expression of sigmaS and sigmaS-independent genes.

References

Feb 15, 1977·Molecular & General Genetics : MGG·M Latil-Damotte, C Lares
Mar 11, 1991·Nucleic Acids Research·M Kajitani, A Ishihama
Jan 1, 1989·Advances in Microbial Physiology·J Preiss, T Romeo
Aug 5, 1987·Journal of Molecular Biology·H H Cheng, H Echols
Jun 1, 1973·Journal of Bacteriology·M J BuettnerH V Rickenberg
Aug 10, 1968·Nature·M T Franze de FernandezJ T August
Jan 1, 1994·Annual Review of Microbiology·P C Loewen, R Hengge-Aronis
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A NobleI Herskowitz
Jan 1, 1994·Journal of Bacteriology·M KajitaniA Ishihama

❮ Previous
Next ❯

Citations

Dec 15, 2000·Molecular Microbiology·R A Lease, M Belfort
Mar 11, 2004·Molecular Microbiology·Poul Valentin-HansenChristina Udesen
Jul 31, 2007·Protein Science : a Publication of the Protein Society·Veronique ArluisonMaxim V Sukhodolets
Sep 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·J W WilsonC A Nickerson
Aug 13, 2009·Nucleic Acids Research·Julia F HopkinsSarah A Woodson
Aug 7, 2009·Acta Biochimica Et Biophysica Sinica·Yinghua Zhang, Guofan Hong
Sep 10, 2010·The Journal of Biological Chemistry·Susan FischerAnita Marchfelder
Dec 20, 2015·Future Microbiology·Joana R FelicianoJorge H Leitão
Oct 6, 2000·Annual Review of Microbiology·A Ishihama
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·O VytvytskaA von Gabain
Nov 4, 2004·Molecular Microbiology·Bijoy K MohantySidney R Kushner
Jul 1, 2004·Molecular Microbiology·Yanpeng DingMatthew K Waldor
Jun 22, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Ayako TakadaMasaaki Wachi
Dec 14, 2006·Molecular Microbiology·Alexandra SittkaJörg Vogel
Sep 4, 2009·Acta Biochimica Et Biophysica Sinica·Yinghua Zhang, Guofan Hong
Aug 11, 2017·Genes & Development·Jiandong Chen, Susan Gottesman
Sep 26, 2006·FEMS Immunology and Medical Microbiology·Trevor K Wagner, Martha H Mulks
May 16, 2007·Molecular Microbiology·Meghan C Lybecker, D Scott Samuels
Mar 20, 2004·European Journal of Biochemistry·Véronique ArluisonPhilippe Regnier
Jun 7, 2011·Annual Review of Microbiology·Aurelia BattestiSusan Gottesman
Dec 18, 2008·Critical Reviews in Biochemistry and Molecular Biology·Elisabeth J Wurtmann, Sandra L Wolin
Jun 14, 2013·Environmental Microbiology Reports·Yotam ShenharEliora Z Ron
Feb 26, 2003·The Journal of Biological Chemistry·David J WorhunskyPaula Jean Schlax
May 6, 2003·Annual Review of Microbiology·R Martin RoopMalcolm E Winkler
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Todd M LinkRichard G Brennan
Jan 7, 2004·Biotechnology and Bioengineering·Pat S Lee, Kelvin H Lee
May 24, 2011·Journal of Bacteriology·Elena Puerta-Fernández, Agustín Vioque
Apr 20, 2018·The EMBO Journal·José M AndradeCecília M Arraiano
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D SchuppliH Weber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.