PMID: 7514589May 1, 1994Paper

The RNA chain elongation rate in Escherichia coli depends on the growth rate

Journal of Bacteriology
U Vogel, K F Jensen

Abstract

We determined the rates of mRNA and protein chain elongation on the lacZ gene during exponential growth on different carbon sources. The RNA chain elongation rate was calculated from measurements of the time elapsing between induction of lacZ expression and detection of specific hybridization with a probe near the 3' end of the mRNA. The elongation rate for the transcripts decreased 40% when the growth rate decreased by a factor of 4, and it always correlated with the rate of translation elongation. A similar growth rate dependency was seen for transcription on the infB gene and on a part of the rrnB gene fused to a synthetic, inducible promoter. However, the untranslated RNA chain specified by the rrnB gene was elongated nearly twice as fast as the two mRNA species encoded by infB and lacZ.

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Citations

Nov 20, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefan Klumpp, Terence Hwa
Oct 16, 2009·Biotechnology Journal·Yiannis N Kaznessis
Jan 27, 2010·Mathematical Modelling of Natural Phenomena·Y R Yamada, C S Peskin
Dec 27, 2012·The Journal of Chemical Physics·Patrick Smadbeck, Yiannis Kaznessis
May 25, 2013·Microbiology·James A J ArpinoKaren Polizzi
Aug 31, 2013·PloS One·Javad NoorbakhshPankaj Mehta
Jan 16, 2016·Molecular Systems Biology·Jennifer A N Brophy, Christopher A Voigt
Aug 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michele CastellanaNed S Wingreen
Aug 16, 2016·PLoS Computational Biology·Tamra HeberlingTomáš Gedeon
Oct 26, 2018·Wiley Interdisciplinary Reviews. RNA·Christina Julius, Yulia Yuzenkova
May 30, 2019·International Journal of Molecular Sciences·Adam B ConnGregor M Blaha
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Hugo B BrandãoLeonid A Mirny
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Apr 6, 2007·BMC Systems Biology·Vassilios Sotiropoulos, Yiannis N Kaznessis
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Stefan Klumpp, Terence Hwa
Jul 29, 2010·Molecular Systems Biology·Nathan E LewisBernhard Ø Palsson
Apr 24, 2010·Science·Jeffrey W Roberts
May 9, 2012·PloS One·Barbara Bryant
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Jan 1, 2016·SIAM Journal on Applied Dynamical Systems·Marcella M GomezRichard M Murray
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