The RNA polymerase I transcription machinery.

Biochemical Society Symposium
Jackie Russell, J C Zomerdijk

Abstract

The rRNAs constitute the catalytic and structural components of the ribosome, the protein synthesis machinery of cells. The level of rRNA synthesis, mediated by Pol I (RNA polymerase I), therefore has a major impact on the life and destiny of a cell. In order to elucidate how cells achieve the stringent control of Pol I transcription, matching the supply of rRNA to demand under different cellular growth conditions, it is essential to understand the components and mechanics of the Pol I transcription machinery. In this review, we discuss: (i) the molecular composition and functions of the Pol I enzyme complex and the two main Pol I transcription factors, SL1 (selectivity factor 1) and UBF (upstream binding factor); (ii) the interplay between these factors during pre-initiation complex formation at the rDNA promoter in mammalian cells; and (iii) the cellular control of the Pol I transcription machinery.

Citations

Nov 27, 2015·Biochimica Et Biophysica Acta·Jonas O P CarlstenClaes M Gustafsson
Feb 6, 2016·Histochemistry and Cell Biology·Klara Weipoltshammer, Christian Schöfer
Feb 4, 2016·Genome Génome / Conseil National De Recherches Canada·Bidénam KakouHélène Glémet
Dec 8, 2009·Journal of Cellular and Molecular Medicine·Stefano RossettiNicoletta Sacchi
Mar 17, 2009·Biochemical and Biophysical Research Communications·Anton LebedevSebastian Iben
Oct 23, 2014·Journal of Cellular Physiology·Le Xuan Truong NguyenBeverly S Mitchell
Jul 28, 2015·Microbiological Research·Hui LuZhengping Jia
Jan 7, 2014·Biochimica Et Biophysica Acta·Jaclyn E QuinRoss D Hannan
Nov 10, 2009·Current Opinion in Structural Biology·Michel WernerJulie Soutourina
Dec 28, 2007·Cell·Claus-D KuhnPatrick Cramer
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Denis DryginIngrid Grummt
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Joseph A D'AlessioRobert Tjian
Jan 5, 2017·European Journal of Human Genetics : EJHG·Bülent KaraAslıhan Tolun
Mar 18, 2016·Biology of Reproduction·Maïmouna Coura KoneAmelie Bonnet-Garnier
Apr 21, 2017·Cell Cycle·Donglai Shen, Robert V Skibbens
Oct 24, 2017·International Journal of Molecular Sciences·Robert CornelisonCharles N Landen
Aug 19, 2007·Journal of Neurochemistry·Katsuhiko Mikoshiba
May 25, 2018·Annual Review of Biophysics·Christoph EngelPatrick Cramer
Jan 18, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Irina LagutinaCesare Galli
Dec 13, 2018·Physiology·Vandré Casagrande Figueiredo, John J McCarthy
Mar 25, 2010·Nature Reviews. Cancer·Jan van RiggelenDean W Felsher
Mar 13, 2014·Oncogene·G PoortingaR D Hannan
Apr 25, 2013·Nature Reviews. Cancer·Megan J BywaterRoss D Hannan
Jun 15, 2014·Journal of Cell Science·Kensaku MuranoKyosuke Nagata
Apr 30, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bader AlmuzzainiPiergiorgio Percipalle

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