Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience. Being a multidisciplinary group of clinical network neuroscience experts based in The Netherlands, we often discuss the current state of the art and possible avenues for future investigations. These discussions revolve around questions like "How do dynamic processes alter the underlying structural network?" and "Can we use network neuroscience for disease classification?" This opinion paper is an incomplete overview of these discussions and expands on ten questions that may potentially advance the field. By no means intended as a review of the current state of the field, it is instead meant as a conversation starter and source of inspiration to others.
An evolutionary theory of schizophrenia: cortical connectivity, metarepresentation, and the social brain
Directionality of coupling from bivariate time series: how to avoid false causalities and missed connections
Simulation of neuronal death and network recovery in a computational model of distributed cortical activity
Research domain criteria (RDoC): toward a new classification framework for research on mental disorders
Emergence of Modular Structure in a Large-Scale Brain Network with Interactions between Dynamics and Connectivity
The anatomical distance of functional connections predicts brain network topology in health and schizophrenia
Identification of reproducible individualized targets for treatment of depression with TMS based on intrinsic connectivity
Improved diagnosis in children with partial epilepsy using a multivariable prediction model based on EEG network characteristics
Epidemic threshold and topological structure of susceptible-infectious-susceptible epidemics in adaptive networks
Exploring mechanisms of spontaneous functional connectivity in MEG: how delayed network interactions lead to structured amplitude envelopes of band-pass filtered oscillations
Anhedonia and reward-circuit connectivity distinguish nonresponders from responders to dorsomedial prefrontal repetitive transcranial magnetic stimulation in major depression
Relating structure and function in the human brain: relative contributions of anatomy, stationary dynamics, and non-stationarities
Structural degree predicts functional network connectivity: a multimodal resting-state fMRI and MEG study
Decreased functional connectivity and disturbed directionality of information flow in the electroencephalography of intensive care unit patients with delirium after cardiac surgery
Circadian and homeostatic modulation of functional connectivity and regional cerebral blood flow in humans under normal entrained conditions
Resting-state networks link invasive and noninvasive brain stimulation across diverse psychiatric and neurological diseases
Accuracy criterion for the mean-field approximation in susceptible-infected-susceptible epidemics on networks
General relationship of global topology, local dynamics, and directionality in large-scale brain networks
Structural white matter changes in descending motor tracts correlate with improvements in motor impairment after undergoing a treatment course of tDCS and physical therapy
Local inhibitory plasticity tunes macroscopic brain dynamics and allows the emergence of functional brain networks
From epidemics to information propagation: striking differences in structurally similar adaptive network models
Estimation of Directed Effective Connectivity from fMRI Functional Connectivity Hints at Asymmetries of Cortical Connectome
The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder
Quantifying the Test-Retest Reliability of Magnetoencephalography Resting-State Functional Connectivity
Slowing of Hippocampal Activity Correlates with Cognitive Decline in Early Onset Alzheimer's Disease. An MEG Study with Virtual Electrodes
Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings
A hierarchy of timescales explains distinct effects of local inhibition of primary visual cortex and frontal eye fields
Functional complexity emerging from anatomical constraints in the brain: the significance of network modularity and rich-clubs
Cortical rich club regions can organize state-dependent functional network formation by engaging in oscillatory behavior
Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations
Inference of direct and multistep effective connectivities from functional connectivity of the brain and of relationships to cortical geometry
Functional connectivity dynamically evolves on multiple time-scales over a static structural connectome: Models and mechanisms
Functional connectivity and network analysis during hypoactive delirium and recovery from anesthesia
Transient networks of spatio-temporal connectivity map communication pathways in brain functional systems
How structure sculpts function: Unveiling the contribution of anatomical connectivity to the brain's spontaneous correlation structure
Changes in resting-state directed connectivity in cortico-subcortical networks correlate with cognitive function in Parkinson's disease
EEG spectral analysis as a putative early prognostic biomarker in nondemented, amyloid positive subjects
Directional information flow in patients with Alzheimer's disease. A source-space resting-state MEG study
Parallel Interdigitated Distributed Networks within the Individual Estimated by Intrinsic Functional Connectivity
Development of structural correlations and synchronization from adaptive rewiring in networks of Kuramoto oscillators
Functional and effective whole brain connectivity using magnetoencephalography to identify monozygotic twin pairs
Age-Varying Associations Between Cigarette Smoking, Sensation Seeking, and Impulse Control Through Adolescence and Young Adulthood
Altering neuronal excitability to preserve network connectivity in a computational model of Alzheimer's disease
Frontal Lobe Connectivity and Network Community Characteristics are Associated with the Outcome of Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease
Brain-Behavior Participant Similarity Networks Among Youth and Emerging Adults with Schizophrenia Spectrum, Autism Spectrum, or Bipolar Disorder and Matched Controls
Task-related effective connectivity reveals that the cortical rich club gates cortex-wide communication
Prospective Validation That Subgenual Connectivity Predicts Antidepressant Efficacy of Transcranial Magnetic Stimulation Sites
Diffusion MRI-based cortical connectome reconstruction: dependency on tractography procedures and neuroanatomical characteristics
A biophysical model of dynamic balancing of excitation and inhibition in fast oscillatory large-scale networks
Scale-freeness or partial synchronization in neural mass phase oscillator networks: Pick one of two?
Functional Brain Networks Are Dominated by Stable Group and Individual Factors, Not Cognitive or Daily Variation
Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E
Localization of the Epileptogenic Zone Using Interictal MEG and Machine Learning in a Large Cohort of Drug-Resistant Epilepsy Patients
Brain structural alterations are distributed following functional, anatomic and genetic connectivity
The evidence-based group-level symptom-reduction model as the organizing principle for mental health care: time for change?
Graph theory approaches to functional network organization in brain disorders: A critique for a brave new small-world
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
Synthetic Genetic Array Analysis
Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.
Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.
Cell Atlas of the Human Eye
Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.
Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.