The Road not Taken: Less Traveled Roads from the TGN to the Plasma Membrane

Membranes
Anne Spang

Abstract

The trans-Golgi network functions in the distribution of cargo into different transport vesicles that are destined to endosomes, lysosomes and the plasma membrane. Over the years, it has become clear that more than one transport pathway promotes plasma membrane localization of proteins. In spite of the importance of temporal and spatial control of protein localization at the plasma membrane, the regulation of sorting into and the formation of different transport containers are still poorly understood. In this review different transport pathways, with a special emphasis on exomer-dependent transport, and concepts of regulation and sorting at the TGN are discussed.

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Citations

Dec 29, 2015·ELife·Effrosyni PapanikouBenjamin S Glick
Sep 24, 2015·Viruses·Danielle J OwenStephen C Graham
Mar 28, 2017·International Journal of Molecular Sciences·Simon GohlkeHans Merzendorfer
Jan 9, 2016·EMBO Reports·Martina HuranovaAnne Spang
Jun 26, 2020·ELife·Jason C Casler, Benjamin S Glick
Mar 13, 2019·The Journal of Cell Biology·Jason C CaslerBenjamin S Glick
Feb 8, 2020·Wellcome Open Research·Stephanie PopaKevin Moreau
Aug 27, 2019·Frontiers in Cell and Developmental Biology·Areti Pantazopoulou, Benjamin S Glick
May 13, 2015·Biology Open·Alejandro F EstradaAnne Spang
Nov 6, 2021·The Journal of Cell Biology·Jason C CaslerBenjamin S Glick

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Methods Mentioned

BETA
protein folding
GTPase
electron microscopy
glycosylation
nucleotide
GTPases

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