PMID: 18411102Jan 1, 1990Paper

The role and regulation of testicular opioids

Trends in Endocrinology and Metabolism : TEM
A Fabbri

Abstract

Endogenous opioids are present in the male gonad and may be involved in the local control of testicular function. Testicular opioids are mainly produced in Leydig cells and exert direct paracrine inhibitory actions on the tubule, which in turn may have indirect Sertoli-cell-mediated effects on Leydig cell steroidogenesis. Gonadotropins and CRF stimulate production of gonadal opioids, and the presence of a gonadotropin milieu appears to be a requisite for the inhibitory paracrine actions of opioids on steroidogenesis. The recognition of such multiple intratesticular hormonal interactions should provide insights into the mechanisms involved in idiopathic infertility in men.

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D L KilpatrickD F Jin
Jan 1, 1989·Molecular Endocrinology·D Kew, D L Kilpatrick
Mar 16, 1989·Biochimica Et Biophysica Acta·T AudhyaB Hutchinson
Nov 13, 1987·Biochemical and Biophysical Research Communications·P L MorrisC W Bardin
Jan 1, 1988·Journal of Steroid Biochemistry·A Fabbri, M L Dufau
May 1, 1987·Molecular Endocrinology·R C ThompsonE Herbert
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A J HsuehW Vale
Aug 1, 1987·Endocrinology·C L Chen, M B Madigan

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Citations

Apr 1, 1991·Molecular and Cellular Endocrinology·A R PierottiC J Molineaux
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·G Verhoeven
Apr 7, 2006·Reproduction, Nutrition, Development·Valdemiro Amaro da SilvaRaul Manhães-de-Castro
Apr 6, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Chin-wern Chan, Philip Peng

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