The role and source of tumor necrosis factor-α in hemorrhage-induced priming for septic lung injury.

Shock
Joanne L Lomas-NeiraAlfred Ayala

Abstract

Tumor necrosis factor α (TNF-α) has been reported to be a key component of the functional priming, of both myeloid and nonmyeloid cells, that is thought to contribute to the lung's increased susceptibility to injury following shock. Not surprisingly, we found that mice deficient in TNF-α exhibited reduced acute lung injury (ALI) resultant from the combined insults of hemorrhagic shock and sepsis. However, we found that when we adoptively transferred neutrophils from mice expressing TNF-α to neutrophil-depleted mice that lacked TNF-α, they were not able to serve as priming stimulus for the development of ALI. Based on these findings, we proposed that resident lung tissue cells mediate TNF-α priming. To begin to unravel the complex signaling pathway of various resident lung tissue cells in TNF-α-induced priming, we compared the effect of local (intratracheal [i.t.]) versus systemic [intravenous (i.v.)] delivery of TNF-α small interference (siRNA). We hypothesized that alternately suppressing expression of TNF-α in lung endothelial (i.v.) or epithelial (i.t.) cells would produce a differential effect in shock-induced ALI. We found that when in vivo siRNA i.t. or i.v. against TNF-α was administered to C57/BL6 mice at 2 h after hemo...Continue Reading

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Citations

Dec 4, 2012·Toxins·Chad L MayerDeborah J Stearns-Kurosawa
Jun 8, 2014·Advanced Drug Delivery Reviews·Olivia M MerkelThomas Kissel
Dec 9, 2015·International Immunopharmacology·Hongyu ZhaoMin Zhao
Jul 15, 2015·The Journal of Surgical Research·Xuerui YanJunfan Fu
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yingshan QiuWanling Liang
Feb 3, 2018·Journal of Leukocyte Biology·Eleanor A FallonAlfred Ayala
Apr 11, 2017·Kona : Powder Science and Technology in Japan·Susanne R Youngren-OrtizMahavir B Chougule
Jan 30, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shumin XuAlfred Ayala
Apr 23, 2019·The Journal of Trauma and Acute Care Surgery·Joaquin CaglianiPing Wang
Sep 1, 2019·Journal of Clinical Medicine·Ahmed S ElshikhaSihong Song
Nov 7, 2019·Drug Development Research·Kamal DuaDinesh Kumar Chellappan
Aug 10, 2017·Brazilian Journal of Biology = Revista Brasleira De Biologia·L A AraújoN J Silva-Júnior
Jan 23, 2021·Stem Cell Reports·Joshua T CohenCraig T Lefort
Jan 18, 2021·Basic & Clinical Pharmacology & Toxicology·Jiyang XuHong Zhang

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