PMID: 9183549Apr 1, 1997Paper

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

Current Opinion in Lipidology
H Kühn, L Chan

Abstract

Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.

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