The role of ¹⁸F-FDG PET/CT for detecting nodal metastases in cN0 head neck cancer patients:a Meta-analysis

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
X Y LiX D Du

Abstract

Objective:The aim of this study is to evaluate the accuracy of ¹⁸F-fluorodeoxyglucose PET/CT(¹⁸F-FDG PET/CT) for the diagnosis of cervical node metastases in cN0 head neck cancer patients. Method:An electronic database search(PubMed,EMBASE,Cochrane Library,WanFang and CNKI databases)was performed. Updated quality assessment of diagnostic accuracy studies-2(QUADAS-2) was used to assess study quality. Data analyses were performed with Meta-Disc1.4. Result:Eight studies were included in the present Meta-analysis. For patient-specific data,the pooled sensitivity,specificity,diagnostic odds ratio(DOR),positive likelihood ratio(PLR),and negative likelihood(NLR)for ¹⁸F-FDG PET/CT were 0.61(95%CI0.52-0.69),0.74(95%CI0.68-0.78),9.62(95%CI2.49-37.22),3.22(95%CI1.55-6.71),and 0.42(95%CI0.24-0.37),respectively. The area under the curve(AUC)was 0.804 1.The evaluation of heterogeneity,calculated the pooled diagnostic odds ratio,gave aQvalue of 21.26(P<0.05)and an I²of 81.2%. Conclusion:The results of meta-analysis suggested that ¹⁸F-FDG PET/CT did not provide better diagnostic accuracy than CT/MRI in detecting cervical node metastases in cN0 head and neck cancer. Considering the high heterogeneity of the included studies,potential value of P...Continue Reading

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