The role of 18F-FDG PET/CT in the management of testicular cancers

Nuclear Medicine Communications
Gary J CookSue Chua

Abstract

The aim of this study was to determine the utility of fluorine-18 fluorodeoxyglucose PET/computed tomography ((18)F-FDG PET/CT) in managing testicular cancer. Sixty-two patients (29 seminoma, 28 nonseminoma and five mixed) underwent 75 (18)F-FDG PET/CT scans (16 scans for primary staging, 44 for residual masses and 15 for rising tumour markers). Follow-up histology, clinical scans and tumour marker results were included for retrospective analysis. (i) Primary staging: eight of 11 patients with equivocal CT scans had true-negative (18)F-FDG PET/CT scans. Five high-risk patients with normal stage 1 CT scans had negative (18)F-FDG PET/CT scans, but two subsequently relapsed. (ii) Residual masses: of the 20 scans interpreted as showing viable disease, five were false positive. Nineteen scans were negative (18 true negative and one false negative). (iii) Rising tumour markers: of the 15 scans, two were false negative and 13 were true positive. (18)F-FDG PET/CT is helpful when primary staging CT scans are equivocal but insufficiently sensitive to predict relapse in high-risk patients with normal CT scans. With residual masses, a negative scan is rarely associated with relapse. (18)F-FDG PET/CT is helpful in defining recurrent disease...Continue Reading

References

Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M H CullenR Jakes
Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J M NuutinenE Salminen
Jun 15, 2000·European Journal of Nuclear Medicine·S F HainR A Huddart
Sep 5, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M De SantisJ Pont
Nov 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Padraig WardeHans von der Maase
Mar 14, 2003·European Journal of Nuclear Medicine and Molecular Imaging·U LassenM Rørth
Mar 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maria De SantisJörg Pont
Apr 20, 2005·European Journal of Radiology·Alexander BechererKurt Kletter
Jul 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert A HuddartUNKNOWN NCRI Testis Tumour Clinical Study Group
May 6, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M de WitR Bares
Nov 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Karin OechsleUNKNOWN German Multicenter Positron Emission Tomography Study Group
Apr 5, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BachnerM De Santis
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M BachnerM De Santis

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Citations

Nov 2, 2019·Abdominal Radiology·Aileen O'SheaMukesh G Harisinghani
Aug 1, 2020·Current Opinion in Urology·Diletta CalabròValentina Ambrosini
May 31, 2019·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Te-Jui HungRodney J Hicks
Sep 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Gurdip K AzadGary J R Cook
Feb 16, 2021·Frontiers in Oncology·Marek MakovníkMichal Chovanec
Mar 13, 2021·Revista española de medicina nuclear e imagen molecular·Francesco DondiRaffaele Giubbini
May 13, 2021·Journal of Pediatric Surgery·Jennifer H AldrinkPeter F Ehrlich
Aug 17, 2018·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F HoneckerA Horwich
Aug 25, 2021·Revista Española De Medicina Nuclear E Imagen Molecular·Francesco DondiRaffaele Giubbini

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Methods Mentioned

BETA
surgical resection
biopsies
biopsy

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