The role of 3D printing in treating craniomaxillofacial congenital anomalies.

Birth Defects Research
Christopher D LopezPaulo G Coelho

Abstract

Craniomaxillofacial congenital anomalies comprise approximately one third of all congenital birth defects and include deformities such as alveolar clefts, craniosynostosis, and microtia. Current surgical treatments commonly require the use of autogenous graft material which are difficult to shape, limited in supply, associated with donor site morbidity and cannot grow with a maturing skeleton. Our group has demonstrated that 3D printed bio-ceramic scaffolds can generate vascularized bone within large, critical-sized defects (defects too large to heal spontaneously) of the craniomaxillofacial skeleton. Furthermore, these scaffolds are also able to function as a delivery vehicle for a new osteogenic agent with a well-established safety profile. The same 3D printers and imaging software platforms have been leveraged by our team to create sterilizable patient-specific intraoperative models for craniofacial reconstruction. For microtia repair, the current standard of care surgical guide is a two-dimensional drawing taken from the contralateral ear. Our laboratory has used 3D printers and open source software platforms to design personalized microtia surgical models. In this review, we report on the advancements in tissue engineering...Continue Reading

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Citations

Aug 28, 2020·Tissue Engineering. Part a·Chen ShenSimon Young
Apr 10, 2020·Frontiers in Bioengineering and Biotechnology·Paula KornMichael Gelinsky
Jan 24, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hannah SpeceSteven M Kurtz
Jul 15, 2021·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Oshri WasserzugAri DeRowe

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