The role of a dairy fraction rich in milk fat globule membrane in the suppression of postprandial inflammatory markers and bone turnover in obese and overweight adults: an exploratory study

Nutrition & Metabolism
Tara S RogersMarta D Van Loan

Abstract

Inflammation is associated with increased bone resorption; the role of inflammation in postprandial bone turnover has not been explored. Consumption of milk fat globule membrane (MFGM) reduces inflammation in animal models. This study aimed to measure postprandial changes in bone turnover after intake of high saturated fat test meals, with- and without the anti-inflammatory ingredient MFGM. Subjects (n = 36 adults) were obese (BMI 30-39.9 kg/m2) or overweight (BMI 25-29.9 kg/m2) with two traits of Metabolic Syndrome. Subjects consumed a different test meal on four occasions at random; blood draws were taken at baseline and 1, 3, and 6 h postprandial. Test meals included whipping cream (WC), WC + MFGM, palm oil (PO) and PO + MFGM. Biomarkers of bone turnover and inflammation were analyzed from all four time points. Test meal (treatment) by time interactions were significant for bone resorption marker C-telopeptide of type 1 collagen (CTX) (p < 0.0001) and inflammatory marker interleukin 10 (IL-10) (p = 0.012). Significant differences in overall postprandial response among test meals were found for CTX and soluble intercellular adhesion molecule (sICAM), with the greatest overall postprandial suppression of CTX occurring in meals...Continue Reading

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Citations

Nov 17, 2017·Nutrients·Gregory H Norris, Christopher N Blesso
Sep 21, 2018·Expert Review of Endocrinology & Metabolism·Rasmus Fuglsang-NielsenPeter Vestergaard
Jul 15, 2018·The American Journal of Clinical Nutrition·Marcia C de Oliveira OttoDariush Mozaffarian
Feb 11, 2020·Journal of Dairy Science·Lauren R BrinkBo Lönnerdal
Jan 13, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A KreitmanS A Shapses
Oct 28, 2019·The Journal of Nutritional Biochemistry·Gregory H NorrisChristopher N Blesso

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Methods Mentioned

BETA
blood draw
blood draws
enzyme linked immune-sorbent assay
ELISA
X-ray

Clinical Trials Mentioned

NCT01811329

Software Mentioned

GraphPad Prism
GraphPad
SAS
Nutrition Data System for NDSR

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