The Role of a Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyol Diet in Nonceliac Gluten Sensitivity

Gastroenterology Research and Practice
P PriyankaJ T Kupec

Abstract

Nonceliac gluten sensitivity (NCGS) is a recently defined clinical entity characterized by intestinal and extraintestinal symptoms associated with gluten ingestion in individuals in whom celiac disease (CD) or wheat allergy (WA) has been excluded. Despite its name and definition, gluten has been shown to precipitate symptoms in only 16-30% of these patients. In addition to gluten, other components of wheat, including fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs), alpha-amylase trypsin inhibitors (ATIs) and wheat germ agglutinin have been implicated in the causation of the symptoms of NCGS, with FODMAPs garnering the most attention. We present a review of the existing literature evaluating the role of FODMAPs in NCGS symptomatology. A systematic review of PubMed, Cochrane, EMBASE, and Google Scholar for keywords fructans, non-celiac gluten sensitivity, NCGS, FODMAPs, and gluten-free diet (GFD) was conducted through a series of advanced searches. Articles related to the use of fructans or FODMAPs were analyzed. FODMAPs were found to be associated with gastrointestinal and extraintestinal symptoms in NCGS. A low FODMAP diet has potential for improvement of clinical symptoms in NCGS. In additio...Continue Reading

References

Feb 7, 2003·Current Pharmaceutical Design·Akira AndohYoshihide Fujiyama
May 29, 2003·Current Pharmaceutical Design·M YoshikawaS Yang
Sep 27, 2006·Journal of the American Dietetic Association·Susan J Shepherd, Peter R Gibson
Jan 25, 2008·Journal of Applied Microbiology·G T MacfarlaneS Macfarlane
Mar 26, 2009·Current Opinion in Allergy and Clinical Immunology·Naoko Inomata
Jan 13, 2011·The American Journal of Gastroenterology·Jessica R BiesiekierskiPeter R Gibson
Sep 29, 2011·The American Journal of Gastroenterology·Raffaella TortoraCarolina Ciacci
Apr 24, 2012·Scandinavian Journal of Gastroenterology·Margit BrottveitBirgitte Boye
Jan 22, 2014·Nature Reviews. Gastroenterology & Hepatology·Heidi M StaudacherKevin Whelan
Apr 18, 2014·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jessica R BiesiekierskiPeter R Gibson
May 17, 2014·Expert Review of Gastroenterology & Hepatology·Caroline J TuckPeter R Gibson
Jun 3, 2014·BMC Medicine·Umberto VoltaUNKNOWN Study Group for Non-Celiac Gluten Sensitivity
Feb 24, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antonio Di SabatinoGino R Corazza
Nov 10, 2015·Gastroenterología y hepatología·Javier Molina-InfanteFermín Mearin
Feb 3, 2016·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Ana Zugasti MurilloEstrella Petrina Jáuregui
May 18, 2016·The American Journal of Gastroenterology·Marlou P M AdriaanseAnita C E Vreugdenhil
Aug 16, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Javier Molina-Infante, Antonio Carroccio
Jan 14, 2017·The American Journal of Pathology·François BlachierDaniel Tomé
Mar 17, 2017·Nutrients·Giulia CatassiCarlo Catassi
Sep 21, 2017·Frontiers in Physiology·Elena LionettiCarlo Catassi
Jan 8, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Francesco TovoliLuigi Bolondi
Jan 25, 2018·JAMA : the Journal of the American Medical Association·Matthew D F McInnesBrian H Willis
Apr 15, 2018·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Walburga DieterichYurdagül Zopf

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Citations

May 31, 2019·Medicina·Anna RoszkowskaBarbara Nieradko-Iwanicka
Jan 18, 2020·Nutrients·Massimo BelliniAlessandra Rossi
Dec 6, 2019·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Wajiha MehtabGovind K Makharia
Jun 3, 2021·Medicina·Feliznando Isidro Cárdenas-TorresNoé Ontiveros

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BETA
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