The role of a mineralocorticoid receptor gene functional polymorphism in the symptom dimensions of persistent ADHD.

European Archives of Psychiatry and Clinical Neuroscience
Gustavo L KortmannClaiton H D Bau

Abstract

Attention-deficit/hyperactivity disorder (ADHD) affects approximately 5 % of school-aged children and 2.5 % of adults. Genetic studies in ADHD have pointed to genes in different neurobiological systems, with relatively small individual effects. The mineralocorticoid receptor is the main receptor involved in the initial triggering of stress response. Therefore, its encoding gene (NR3C2) is a candidate for psychiatric disorder studies, including ADHD, and behavioral phenotypes. There is evidence that the Val allele of the MRI180V polymorphism (rs5522) increases the risk of depression, attention and cognitive deficits. We investigated the possible role of the mineralocorticoid receptor gene in the symptom dimensions and susceptibility to persistent ADHD. We compared genotype and allele frequencies in 478 adult patients with ADHD and 597 controls and symptom dimensions in 449 patients and 132 controls. Diagnoses were based on the DSM-IV criteria. ADHD symptom dimensions were investigated with SNAP-IV for ADHD severity and Barkley scales for severity and impairment. Carriers of the Val allele presented higher inattention, hyperactivity/impulsivity and impairment scores, while genotype and allele frequencies did not differ between pa...Continue Reading

References

Oct 21, 1991·Nucleic Acids Research·D K Lahiri, J I Nurnberger
Dec 1, 1985·Acta Psychiatrica Scandinavica·A Meijer
Sep 1, 1981·American Journal of Physical Anthropology·L M Schell
Jan 1, 1997·Neuroscience and Biobehavioral Reviews·M Weinstock
Jun 17, 1998·Endocrine Reviews·E R De KloetM Joëls
Jul 1, 1998·Biological Psychiatry·J A KingS Barrett
Apr 12, 2000·Kidney International·E R de KloetW de Jong
May 7, 2003·Neuroscience and Biobehavioral Reviews·S MaccariO Van Reeth
Jun 12, 2003·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Christophe Antonio-NkondjioDidier Fontenille
Jan 14, 2004·Psychological Bulletin·Kent E HutchisonAngela Bryan
May 12, 2004·Molecular and Cellular Endocrinology·Damien Le MenuetMarc Lombès
May 12, 2004·Molecular and Cellular Endocrinology·John W Funder
Jan 20, 2006·Psychological Medicine·Joseph BiedermanStephen V Faraone
May 11, 2006·European Archives of Psychiatry and Clinical Neuroscience·Eugenio H GrevetPaulo Belmonte-de-Abreu
May 30, 2006·Journal of Psychiatric Research·Frouke E P L SondeijkerFrank C Verhulst
Oct 5, 2006·The Journal of Clinical Endocrinology and Metabolism·Roel H DeRijkE Ronald de Kloet
Oct 13, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Christian OtteMichael Kellner
Nov 14, 2006·Journal of Psychiatric Research·Aline G FischerPaulo Belmonte-de-Abreu
Nov 30, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maris KuningasDiana van Heemst
May 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·J FayyadR Jin
Jun 2, 2007·The American Journal of Psychiatry·Guilherme PolanczykLuis Augusto Rohde
Nov 13, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Tinca J C PoldermanDorret I Boomsma
Jan 30, 2008·Molecular Psychiatry·W BerrettiniV Mooser
Mar 11, 2008·Psychoneuroendocrinology·Halina LackschewitzBirgit Kröner-Herwig
Apr 22, 2008·European Journal of Pharmacology·Roel H DerijkFrans G Zitman
Oct 1, 2008·Neuroscience and Biobehavioral Reviews·Enrico Alleva, Nadia Francia
Nov 15, 2008·Journal of Psychiatric Research·Rafael G KaramEugenio H Grevet
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Viktória SimonIstván Bitter
Apr 23, 2009·Human Genetics·Barbara FrankeStephen V Faraone
May 29, 2009·Journal of Attention Disorders·Stacey L BlaseDavid L Rabiner
Jun 10, 2009·Human Genetics·Ian R GizerIrwin D Waldman
Jul 3, 2009·Neuroimmunomodulation·Roel H Derijk
Sep 15, 2009·Depression and Anxiety·Charles F GillespieKerry J Ressler
Oct 3, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·Gitta H LubkeDorret I Boomsma
Oct 3, 2009·Journal of the American Academy of Child and Adolescent Psychiatry·James ColePeter Mcguffin

❮ Previous
Next ❯

Citations

Mar 5, 2013·European Archives of Psychiatry and Clinical Neuroscience·Andrea Schmitt, Peter Falkai
Feb 4, 2014·European Archives of Psychiatry and Clinical Neuroscience·Lucas A de AzeredoClaiton H D Bau
Apr 2, 2013·Journal of Neural Transmission·Diego L RovarisClaiton H D Bau
Jun 7, 2015·American Journal of Hypertension·Alessandra Mileni Versuti RitterHeitor Moreno
Jul 8, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Carolina M CarvalhoSintia I Belangero

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Tatiana RomanM H Hutz
European Psychiatry : the Journal of the Association of European Psychiatrists
C R GarciaEugenio H Grevet
Journal of the American Academy of Child and Adolescent Psychiatry
Russell A Barkley, Mariellen Fischer
© 2021 Meta ULC. All rights reserved