The Role of Accessory Cells in Islet Homeostasis.

Current Diabetes Reports
Shiue-Cheng TangMartha Campbell-Thompson

Abstract

Scattered throughout the pancreas, the endocrine islets rely on neurovascular support for signal relay to regulate hormone secretion and for maintaining tissue homeostasis. The islet accessory cells (or components) of neurovascular tissues include the endothelial cells, pericytes, smooth muscle cells, neurons (nerve fibers), and glia. Research results derived from experimental diabetes and islet transplantation indicate that the accessory cells are reactive in islet injury and can affect islet function and homeostasis in situ or in an ectopic environment. Recent advances in cell labeling and tissue imaging have enabled investigation of islet accessory cells to gain insights into their network structures, functions, and remodeling in disease. It has become clear that in diabetes, the islet neurovascular tissues are not just bystanders damaged in neuropathy and vascular complications; rather, they participate in islet remodeling in response to changes in the microenvironment. Because of the fundamental differences between humans and animal models in neuroinsular cytoarchitecture and cell proliferation, examination of islet accessory cells in clinical specimens and donor pancreases warrants further attention.

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Citations

Apr 3, 2020·Journal of Molecular Cell Biology·Jinglong Guo, Wenxian Fu
Sep 8, 2020·Diabetologia·Mark A AtkinsonKlaus H Kaestner
Oct 11, 2020·Science Advances·Alexandra AlvarssonSarah A Stanley
Feb 2, 2021·Frontiers in Endocrinology·Luciana Mateus Gonçalves, Joana Almaça
Mar 24, 2021·Scientific Reports·Martha Campbell-ThompsonMark A Atkinson
May 14, 2021·Frontiers in Endocrinology·Martha Campbell-Thompson, Shiue-Cheng Tang
Jul 20, 2021·American Journal of Physiology. Endocrinology and Metabolism·Andraž StožerJurij Dolenšek

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