The role of acoustofluidics in targeted drug delivery

Biomicrofluidics
Nilanjana BoseSuman Chakraborty

Abstract

With the fast development of acoustic systems in clinical and therapeutic applications, acoustically driven microbubbles have gained a prominent role as powerful tools to carry, transfer, direct, and target drug molecules in cells, tissues, and tumors in the expanding fields of targeted drug delivery and gene therapy. The aim of the present study is to establish a biocompatible acoustic microfluidic system and to demonstrate the generation of an acoustic field and its effects on microbubbles and biological cells in the microfluidic system. The acoustic field creates non-linear oscillations of the microbubble-clusters, which results in generation of shear stress on cells in such microsystems. This effectively helps in delivering extracellular probes in living cells by sonoporation. The sonoporation is investigated under the combined effects of acoustic stress and hydrodynamic stress during targeted drug and gene delivery.

References

Aug 1, 1990·Journal of the American College of Cardiology·S B FeinsteinP M Shah
Sep 1, 1968·Investigative Radiology·R Gramiak, P M Shah
Jul 4, 1998·European Journal of Radiology·F CalliadaM G Sommaruga
May 21, 1999·The Journal of the Acoustical Society of America·M WardJ F Chiu
Jun 17, 2000·Ultrasound in Medicine & Biology·D L Miller, J Quddus
Oct 13, 2000·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M McCullochD Adams
Oct 29, 2000·Ultrasound in Medicine & Biology·M WardJ F Chiu
Feb 24, 2001·Cancer Metastasis Reviews·F S FosterD E Goertz
May 19, 2001·BMJ : British Medical Journal·M J BlomleyD O Cosgrove
Apr 27, 2002·European Journal of Radiology·Evan C UngerRachel Quigley
Jul 13, 2002·Ultrasound in Medicine & Biology·Peter A FrenkelPaul A Grayburn
May 9, 2003·Nature·Philippe Marmottant, Sascha Hilgenfeldt
Mar 2, 2005·Nature Reviews. Drug Discovery·Samir Mitragotri
Mar 11, 2005·Advanced Drug Delivery Reviews·Sophie Mehier-Humbert, Richard H Guy
Sep 24, 2005·Ultrasound in Medicine & Biology·Grzegorz KorpantyRolf A Brekken
Oct 21, 2005·Chest·Michal Barak, Yeshayahu Katz
Nov 22, 2005·Expert Opinion on Drug Delivery·William G PittBryant J Staples
Mar 25, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Annemieke van WamelNico de Jong
Aug 30, 2006·European Journal of Radiology·David Cosgrove
Jul 27, 2007·Annual Review of Biomedical Engineering·Katherine FerraraMark Borden
Sep 21, 2007·Expert Opinion on Drug Delivery·Joseph L Bull
Jan 1, 1986·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·D L Miller
Feb 21, 2009·Physics in Medicine and Biology·Shengping QinKatherine W Ferrara
Apr 28, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Pavel V Zinin, John S Allen
May 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ryo SuzukiKazuo Maruyama
Aug 24, 2010·Drug Discovery Today·Mariame A HassanTakashi Kondo
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Boris KrasovitskiEitan Kimmel
May 26, 2011·International Journal of Pharmaceutics·Michael C CochranMargaret A Wheatley
Sep 21, 2012·Lab on a Chip·Xiaoyun DingTony Jun Huang
Feb 6, 2013·Theranostics·Shashank R Sirsi, Mark A Borden
May 15, 2013·Drug Design, Development and Therapy·Stuart IbsenSadik Esener
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Feng GuoTony Jun Huang

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Citations

Oct 1, 2015·Biomicrofluidics·Brigitte Stadler
Dec 13, 2019·Small·Alinaghi SalariScott S H Tsai
Nov 12, 2018·Medical & Biological Engineering & Computing·Hritwick BanerjeeHongliang Ren
Apr 29, 2020·Biomicrofluidics·Connor S CentnerJonathan A Kopechek
Dec 1, 2020·ACS Nano·Yuliang XieTony Jun Huang

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