The Role of Actin Cytoskeleton in Dendritic Spines in the Maintenance of Long-Term Memory

Frontiers in Molecular Neuroscience
Sreetama Basu, Raphael Lamprecht

Abstract

Evidence indicates that long-term memory formation involves alterations in synaptic efficacy produced by modifications in neural transmission and morphology. However, it is not clear how such alterations induced by learning, that encode memory, are maintained over long period of time to preserve long-term memory. This is especially intriguing as the half-life of most of the proteins that underlie such changes is usually in the range of hours to days and these proteins may change their location over time. In this review we describe studies that indicate the involvement of dendritic spines in memory formation and its maintenance. These studies show that learning leads to changes in the number and morphology of spines. Disruption in spines morphology or manipulations that lead to alteration in their number after consolidation are associated with impairment in memory maintenance. We further ask how changes in dendritic spines morphology, induced by learning and reputed to encode memory, are maintained to preserve long-term memory. We propose a mechanism, based on studies described in the review, whereby the actin cytoskeleton and its regulatory proteins involved in the initial alteration in spine morphology induced by learning are ...Continue Reading

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Citations

Aug 11, 2019·Experimental Biology and Medicine·Sarah A KingXiaoyang Wu
Oct 2, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chaoyi GuAndrew G Ewing
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Methods Mentioned

BETA
GTPase
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