The role of activated cytotoxic T cells in etiopathogenesis of periodontal disease: does it harm or does it heal?

Scientific Reports
Emine CifcibasiSerdar Cintan

Abstract

The objective of this study was to determine the phenotypic profile of blood mononuclear cells, specifically CD8(+)/CD28(+) cells, in patients with generalized aggressive periodontitis (GAgP) and chronic periodontitis (CP) in peripheral blood and in blood obtained from periodontal defect site which might contribute to tissue damage. 13 GAgP, 11 chronic periodontitis (CP) and 5 healthy controls (H) were included in the study. Plaque index (PI), bleeding on probing (BoP), periodontal probing depth (PPD) and clinical attachment level (CAL) were recorded. Blood from the base of periodontal defect site and peripheral blood from the antecubital vein were obtained. Relative counts of CD45(+), CD3(+), CD4(+), CD8(+)/CD28(+), CD8(+)/CD28(-), CD19(+), CD16(+)/CD56(+)/CD3, CD3(+)/CD16(+)/CD56(+) receptors were determined with two color flow cytometry using monoclonal antibodies. BoP, PPD and CAL were significantly higher in both periodontitis groups than healthy controls (p <0.05). Activated cytotoxic T cells, CD8(+)/CD28(+) cells, were significantly elevated in GAgP and CP groups compared to HC both in blood obtained from defect site and blood obtained from systemic circulation (p <0.05). GAgP and CP patients have an increased levels of ...Continue Reading

References

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Citations

Jan 27, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·D S MichaudE Giovannucci
Dec 27, 2019·Journal of Periodontal Research·Raphael J G da MottaCamila Tirapelli
Jul 13, 2017·Current Medical Research and Opinion·Omer DizdarEzel Berker
Dec 31, 2020·Medicinal Research Reviews·Cheng FangXian-Tao Zeng
Mar 11, 2021·Periodontology 2000·Jessica D Hathaway-Schrader, Chad M Novince

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

BD FACSDiva
FACSDiva

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