The role of activated neutrophils in the early stage of equine laminitis

The Veterinary Journal
Geoffroy de la Rebière de Pouyade, Didier D A Serteyn

Abstract

Despite ongoing research and a widening range of treatment options, laminitis remains a severely damaging condition with poorly understood pathophysiology. Results obtained from cytokine regulation studies during the last decade have highlighted the inflammatory nature of laminitis. This review will describe the role of systemic activation and local infiltration of neutrophils in laminar tissues in the induction of laminitis. Particular emphasis is placed on the role of neutrophil activation in subsequent vascular dysfunction and oxidative and proteolysis imbalances that are pathways previously implicated in laminitis. Neutrophils, by the way of their interdependent relationship with endothelial cells and keratinocytes, dramatically increase the inflammatory response culminating in the failure of the laminar dermal-epidermal interface.

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Citations

May 27, 2014·Veterinary Immunology and Immunopathology·Mary K SheatsSamuel L Jones
Apr 17, 2012·Applied and Environmental Microbiology·Marlie BothaLeon M T Dicks
Mar 26, 2013·Veterinary Immunology and Immunopathology·Samantha M SteelmanBhanu P Chowdhary
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Oct 17, 2017·Frontiers in Veterinary Science·Emily Medlin MartinSamuel L Jones
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Nov 20, 2019·Toxicologic Pathology·Qingqiu Yang, Mandi J Lopez
Jan 5, 2021·Frontiers in Veterinary Science·Shuaichen LiNa Zhang
Sep 3, 2020·Comparative Immunology, Microbiology and Infectious Diseases·Wael El-DeebAbdulrahman Alhaider

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