The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies

Trends in Immunology
Meng Michelle XuYang-Xin Fu

Abstract

Accumulating evidence indicates that the efficacy of tumor-targeted therapies relies on the host immune response, including targeted small-molecule and antibody approaches that were not previously thought to have an immune component. Here, we review the current understanding of how targeted therapies on tumor cells could have a major impact on the immune response, and how this relates to the therapeutic efficacy of these approaches. In this context, we evaluate different strategies that combine targeted therapies with immunotherapy approaches, and discuss past and ongoing clinical trials. We highlight gaps in knowledge, and argue that significant progress for combined therapies will require a better understanding of the complex interactions between immune cells, the tumor, and the tumor microenvironment (TME) in different cancer settings.

References

Aug 28, 2001·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Baselga, J Albanell
Oct 13, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Baselga
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Jul 3, 2002·The Journal of Clinical Investigation·Khadija RafiqRaphael Clynes
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William Pao, Vincent A Miller
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan S MelnickJeremy S Caldwell
Sep 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael C HeinrichJonathan A Fletcher
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marissa N BalakWilliam Pao
Nov 15, 2006·Immunological Reviews·Lorenzo MorettaAlessandro Moretta
Dec 8, 2006·The New England Journal of Medicine·Brian J DrukerUNKNOWN IRIS Investigators
Aug 3, 2007·The Journal of Clinical Investigation·Gary A Koretzky
Jan 15, 2008·Cancer Immunology, Immunotherapy : CII·Takuya OsadaMichael A Morse
Feb 1, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles D BlankeHeikki Joensuu
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James H FinkeRonald Bukowski
Apr 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Linda C BenavidesGeorge E Peoples
Mar 23, 2010·Trends in Molecular Medicine·Barbara SeligerJim Finke
May 26, 2010·Nature Reviews. Immunology·Christian KurtsPercy A Knolle
Jun 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hamouda BoussenNeil Spector
Apr 13, 2011·Proceedings of the National Academy of Sciences of the United States of America·John StaggMark J Smyth
Apr 19, 2011·Journal of Immunotherapy·Hyunsu KimChi-Dug Kang
Aug 13, 2011·The New England Journal of Medicine·David L PorterCarl H June
Dec 14, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·James S WilmottRichard A Scolyer
Aug 2, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jahan S KhaliliGregory Lizée
Sep 20, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xuanming YangYang-Xin Fu
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yuhui HuangMark C Poznansky
Oct 26, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiaofeng JiangF Stephen Hodi
Jan 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dennie T FrederickJennifer A Wargo
Jan 22, 2013·Current Opinion in Hematology·David MarinJohn Goldman
Feb 28, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raghvendra M SrivastavaRobert L Ferris
Apr 30, 2013·The Journal of Biological Chemistry·Franziska StehleBarbara Seliger
Jun 4, 2013·The New England Journal of Medicine·Omid HamidAntoni Ribas
Jun 21, 2013·The New England Journal of Medicine·Michael L WangKristie A Blum
Jun 21, 2013·The New England Journal of Medicine·John C ByrdSusan O'Brien
Jul 12, 2013·European Journal of Immunology·Lára HannesdóttirWolfgang Doppler

❮ Previous
Next ❯

Citations

Aug 20, 2016·Molecular Pharmaceutics·Muhammad SarfrazRaimar Löbenberg
Aug 4, 2018·Essays in Biochemistry·Peter T Harrison, Paul H Huang
Jun 4, 2016·Journal of Leukocyte Biology·Anna E VilgelmAnn Richmond
Jul 1, 2017·Journal of the Royal Society, Interface·Anna KonstorumReinhard C Laubenbacher
Jun 21, 2019·International Journal of Molecular Sciences·Loredana AlboniciRoberto Bei
Dec 18, 2019·Cellular & Molecular Immunology·Zhida LiuYang-Xin Fu
Mar 17, 2020·Critical Reviews in Oncology/hematology·Antonino MusolinoMaria Michiara
Mar 12, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yong LiangYang-Xin Fu
Jun 20, 2021·Cancer Research·Li-Chung TsaoZachary C Hartman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.