The role of adding metformin in insulin-resistant diabetic pregnant women: a randomized controlled trial

Archives of Gynecology and Obstetrics
Moustafa Ibrahim IbrahimMohammed Faris

Abstract

The aim of the present study is to assess the impact of adding oral metformin to insulin therapy in pregnant women with insulin-resistant diabetes mellitus. The current non-inferiority randomized controlled trial was conducted at Ain Shams University Maternity Hospital. The study included pregnant women with gestational or pre-existing diabetes mellitus at gestations between 20 and 34 weeks, who showed insulin resistance (defined as poor glycemic control at a daily dose of ≥1.12 units/kg). Recruited women were randomized into one of two groups: group I, including women who received oral metformin without increasing the insulin dose; and group II, including women who had their insulin dose increased. The primary outcome was maternal glycemic control. Secondary outcomes included maternal bouts of hypoglycemia, need for another hospital admission for uncontrolled diabetes during pregnancy, gestational age at delivery, mode of delivery, birth weight, birth trauma, congenital anomalies, 1- and 5-min Apgar score, neonatal hypoglycemia, need for neonatal intensive care unit (NICU) admission and adverse neonatal outcomes. A total number of 154 women with diabetes mellitus with pregnancy were approached; of them 90 women were eligible a...Continue Reading

References

May 9, 2000·The American Journal of Clinical Nutrition·N F Butte
Jun 28, 2002·Diabetes·John P KirwanPatrick M Catalano
Feb 19, 2004·Nutrition Reviews·Lais U Monzillo, Osama Hamdy
May 7, 2004·Current Opinion in Obstetrics & Gynecology·Robert J NormanWilliam M Hague
Jun 17, 2004·JAMA : the Journal of the American Medical Association·Allison A HedleyKatherine M Flegal
Nov 17, 2007·Current Opinion in Obstetrics & Gynecology·Nisha KapoorHassan Shehata
May 9, 2008·The New England Journal of Medicine·Janet A RowanMiG Trial Investigators
Dec 23, 2009·Obstetrics and Gynecology·Lisa E MooreLuis B Curet
Jun 15, 2010·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jean Carl SilvaAnna Maria Bertini
Aug 6, 2010·Obstetrics and Gynecology Clinics of North America·Gabriella Pridjian, Tara D Benjamin
Nov 19, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·H IjäsT Raudaskoski
Jan 8, 2011·Expert Opinion on Drug Safety·Ana Cristina MaymoneJean-Luc Ardilouze
May 4, 2011·European Journal of Clinical Pharmacology·Cláudia de Oliveira BaraldiRicardo Carvalho Cavalli
Apr 17, 2012·Journal of Perinatal Medicine·Jean Carl SilvaAnna Maria Bertini
Oct 17, 2012·Diabetes Research and Clinical Practice·Shirin NiromaneshSoheila Akbari
Oct 26, 2012·American Journal of Perinatology·M Ashley HickmanRobert Strauss

Citations

Dec 31, 2014·Archives of Gynecology and Obstetrics·Genxia LiYuanyuan Li
Aug 24, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ye Feng, Huixia Yang
Jul 21, 2016·BMC Pregnancy and Childbirth·Denice S FeigMiTy Collaborative Group
May 7, 2016·Diabetic Medicine : a Journal of the British Diabetic Association·S ButaliaL Donovan
Jan 28, 2017·Diabetes, Obesity & Metabolism·Susan G GrayPeter J Little
Mar 7, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Claudia CaissuttiVincenzo Berghella
Nov 6, 2017·The Cochrane Database of Systematic Reviews·Julie BrownCaroline A Crowther
Apr 28, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Fan PingXinhua Xiao
Jun 2, 2018·Therapeutic Advances in Drug Safety·Thomas M PolasekTilenka R J Thynne

Related Concepts

Blood Glucose
Fasting
Gestational Age
Intravenous Glucose Tolerance Test
Hyperglycemia, Postprandial
Hypoglycemic Effect
Novolin
Insulin Sensitivity
Glucophage
Pregnancy in Diabetics

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.