The role of adenosine in mediating vasodilatation in mesenteric circulation of the rat in acute and chronic hypoxia

The Journal of Physiology
R Mian, J M Marshall

Abstract

1. We have compared the roles of adenosine in mediating dilator responses to acute hypoxia in mesenteric microcirculation of control, normoxic (N) rats and in chronically hypoxic (CH) rats kept in an hypoxic chamber at 10% O2 for 3-4 weeks. 2. In fifteen N rats, acute hypoxia (breathing 6% O2 for 3 min) induced mean increases in the diameter of arterial vessels of mesentery (whose internal diameter was 10-350 microns) of 8.0 +/- 1.9% (mean +/- S.E.M.) and of venous vessels (whose internal diameter was 12-360 microns) of 10.4 +/- 2.6%. These diameter changes were reduced by approximately 30% when the adenosine receptor antagonist 8-sulpho-phenyltheophylline (8-SPT, 10(-3) M) was applied topically to the mesentery. 3. In a further six N rats, topical application of graded concentrations of adenosine (10(-7)-10(-3) M) to the mesentery evoked graded increases in the diameter of all arterial and venous vessels, maximum increases with 10(-3) M being 12.5 +/- 3.3 and 8.4 +/- 4.3%, respectively; these responses were abolished by 8-SPT. 4. By contrast, in fourteen CH rats, the smaller change in inspirate from 10 to 8% O2 induced increases in diameter of arterial and venous vessels which had control diameters that were comparable to thos...Continue Reading

Citations

Apr 30, 2008·Purinergic Signalling·Manuela MoratoAntónio Albino-Teixeira
Nov 3, 2001·The Journal of Physiology·N J Edmunds, J M Marshall
May 25, 2010·Autonomic Neuroscience : Basic & Clinical·Mitsutaka SugimuraHitoshi Niwa
Sep 18, 2007·Microvascular Research·Luciana N TorresIvo P Torres Filho
Feb 7, 2006·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jay S Naik, Benjimen R Walker
Jul 5, 2008·Autonomic Neuroscience : Basic & Clinical·Mitsutaka SugimuraHitoshi Niwa
Apr 12, 2000·Acta Physiologica Scandinavica·J M Marshall
Aug 12, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J M Marshall
Feb 12, 2013·The Journal of Pharmacology and Experimental Therapeutics·Sutheera SangsiriHui Xu
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·F GustafssonN Holstein-Rathlou
Oct 2, 1998·The American Journal of Physiology·T K CaudillB R Walker

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