The role of adenosine receptors in mood and anxiety disorders

Journal of Neurochemistry
Dietrich van CalkerTsvetan Serchov

Abstract

Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse biological functions and have a role in various conditions, such as cerebral and cardiac ischemia, immune and inflammatory disorders and cancer. In the brain, they limit potentially dangerous over excitation, but also regulate mechanisms essential in sleep and psychiatric disorders. In this review, we discuss the role of adenosine receptors in mood and anxiety disorders. Activation of A2A receptors is associated with increased depression-like symptoms, while increased A1 receptors signaling elicits rapid antidepressant effects. Indeed, several lines of evidence demonstrate that the therapeutic effects of different non-pharmacological treatments of depression, like sleep deprivation and electroconvulsive therapy are mediated by A1 receptor up-regulation or activation. In addition, A1 receptors may also play a role in the antidepressant effects of transcranial direct current stimulation and deep brain stimulation. As a potential downstream mechanism, which facilitates the antidepressant effects of A1 receptors, we propose a crosstalk between adenosinergic and glutamatergic systems mediated via synaptic plasticity protein Homer1a and α-amino-3...Continue Reading

References

Mar 1, 1985·Archives of General Psychiatry·D S CharneyP I Jatlow
May 1, 1988·The American Journal of Psychiatry·M A LeeO G Cameron
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C LondosJ Wolff
Oct 1, 1995·British Journal of Pharmacology·N JainT W Stone
May 23, 1997·Science·T Porkka-HeiskanenR W McCarley
May 26, 1998·Psychopharmacology·C FlorioR Vertua
Mar 4, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K BiberD van Calker
Dec 7, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K BiberD van Calker
Apr 3, 2001·The International Journal of Neuropsychopharmacology·Jürgen Deckert
May 9, 2001·The Journal of Pharmacy and Pharmacology·Y HigashiA Tsuji
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·B JohanssonB B Fredholm
Sep 15, 2001·Cardiovascular Research·K Mubagwa, W Flameng
May 25, 2002·Medical Hypotheses·R Machado-VieiraF Kapczinski
Jun 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karen AlseneHarriet de Wit
Dec 10, 2003·Neurology·Malika El YacoubiJean-Marie Vaugeois
Dec 11, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Steven P HamiltonJames A Knowles
Aug 18, 2004·Progress in Neurobiology·Radhika BasheerRobert W McCarley
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Mar 19, 2005·Neuroscience Letters·Pok LamShih-Jen Tsai
Jun 21, 2005·Nature Neuroscience·Zhi-Li HuangOsamu Hayaishi
Aug 25, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Christa HohoffHarriet de Wit
Aug 30, 2005·Trends in Pharmacological Sciences·György HaskóPeter Illes
Sep 9, 2005·Neuroreport·Felipe FregniAlvaro Pascual-Leone
Dec 13, 2005·Neurochemical Research·Dietrich van Calker, Knut Biber
Jan 31, 2006·Brain Research·Peter J MarroMaria Delivoria-Papadopoulos
May 24, 2006·Pflügers Archiv : European journal of physiology·Nicola KingM Saadeh Suleiman

❮ Previous
Next ❯

Citations

Mar 18, 2020·Brain Sciences·Francesco BartoliGiuseppe Carrà
May 14, 2020·Neural Plasticity·Ella E BauerPeter J Clark
Mar 7, 2020·EMBO Reports·Helena Caria Martins, Gerhard Schratt
Oct 23, 2020·Journal of Evidence-based Integrative Medicine·Noriko ShinjyoJulia Green
Dec 8, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana I GomesSandra H Vaz
Dec 29, 2020·Frontiers in Neuroscience·Janine Aly, Olivia Engmann
Feb 20, 2021·Pharmacology & Therapeutics·Aleksandra SzopaPiotr Wlaź
Mar 26, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mohd Faizal Mohd ZulkiflyWalter Paulus
May 1, 2021·Frontiers in Pharmacology·Roberto F AlmeidaElaine Elisabetsky
May 11, 2021·Curēus·Raphael A O BertasiGeorge Pujalte
Jul 24, 2021·European Journal of Pharmacology·Anusha GovindulaJayesh Mudgal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.