The role of adhesion molecules in multiple myeloma

Acta Haematologica
G CookI M Franklin

Abstract

The neoplastic plasma cells of multiple myeloma differ from normal plasma cells and other B-cell malignancies by an almost exclusive homing to the bone marrow microenvironment which clearly provides the appropriate support, both physical and cytokine, to mediate clonal proliferation and terminal differentiation. Cellular adhesion molecules are involved in the homing of malignant plasma cells to the bone marrow, the production of growth factors and the recirculation of these tumour cells in the advanced stages of disease. Neoplastic plasma cells express H-CAM (CD44), VLA-4 (CD49d/CD29), ICAM-1 (CD54), N-CAM (CD56) and LFA-3 (CD58). In addition VLA-5 (CD49e/CD29) expression seems to be related to cells with less proliferative potential and more potential for paraprotein production. In addition there are fundamental changes in the bone marrow stroma of patients with multiple myeloma including altered composition of the extracellular matrix, increased growth capability of the cellular elements and increased synthesis of interleukin-6 and interleukin-3, which are features postulated to localise and promote growth of the circulating neoplastic progenitors in the bone marrow. However, the evidence to date does not fully explain the in...Continue Reading

Citations

Apr 23, 2010·Cancer Metastasis Reviews·Scott A Bergfeld, Yves A DeClerck
Aug 26, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Ander AbarrategiJavier García-Castro
Mar 2, 2013·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Shano NaseemSoniya Nityanand
May 7, 2002·Nature Reviews. Cancer·W Michael Kuehl, P Leif Bergsagel
Oct 16, 1999·British Journal of Haematology·I TuressonF Wislöff
Aug 30, 2013·Molecular Cytogenetics·Walid Al AchkarThomas Liehr
May 8, 2014·International Reviews of Immunology·Leonardo MirandolaMaurizio Chiriva-Internati
Jun 6, 2003·Histopathology·R ChettyK Gatter
Oct 5, 2010·Journal of Surgical Oncology·Sumiya IshigamiShoji Natsugoe
Oct 8, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael G AlexandrakisDespina S Kyriakou
Oct 20, 1999·Blood Reviews·G Cook, J D Campbell
Aug 4, 2005·Immunobiology·Isebrand PrinslooDaniel Benharroch
Nov 24, 1999·The Journal of Biological Chemistry·B ZhouP H Weigel
Jun 20, 2002·European Journal of Haematology·Gunnel SundströmAnna Engström-Laurent
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fatemeh NoroziNajmaldin Saki
Jan 14, 2021·Cancers·Teru Hideshima, Kenneth C Anderson
Dec 6, 2000·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N G KastrinakisC Kittas
Jan 8, 2000·Hematology/oncology Clinics of North America·T E Witzig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
Shano NaseemSoniya Nityanand
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
G ThanV Briese
© 2022 Meta ULC. All rights reserved