The role of adipocyte-specific IL-6-type cytokine signaling in FFA and leptin release

Adipocyte
Stephan Wueest, Daniel Konrad

Abstract

High secretion of interleukin (IL)-6 from white adipose tissue may contribute to metabolic complications in obesity. We have recently shown that IL-6-type cytokine signaling in adipocytes is involved in the development of obesity-associated hepatic insulin resistance and steatosis. In addition, we revealed that adipocyte-specific IL-6 signaling ameliorates glucose metabolism in obesity via enhancing insulin secretion. Mechanistically, IL-6 induces the release of free fatty acid (FFA) and leptin from adipocytes thereby affecting liver metabolism and pancreatic β-cell function, respectively. This commentary further discusses the role of adipocyte-specific IL-6-type cytokine signaling in the regulation of FFA and leptin release. In particular, we outline depot-specific differences in IL-6-induced basal release of the two aforementioned factors. Moreover, we provide evidence that insulin's effect on the release of FFA and leptin is adipose depot-dependent. We conclude that adipose depot-specific targeting of the IL-6 signaling pathway may be a novel approach to blunt obesity-associated metabolic complications.

References

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Citations

Aug 31, 2019·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Timothy S OdermattDaniel Konrad
Jul 28, 2020·American Journal of Physiology. Endocrinology and Metabolism·Stephan Wueest, Daniel Konrad
May 21, 2020·International Journal of Molecular Sciences·Thomas E ZapadkaPatricia R Taylor
Sep 4, 2020·International Journal of Molecular Sciences·Olivia PatsalosHubertus Himmerich
Jan 26, 2020·Proceedings of the National Academy of Sciences of the United States of America·Myoung Sook HanRoger J Davis
Oct 20, 2020·Frontiers in Endocrinology·Ayelén Ivana Pesce VigliettiMaría Victoria Delpino
May 8, 2021·Mucosal Immunology·Pablo C AlarconSenad Divanovic
Aug 8, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria SorrentiLuca Vanella
Sep 17, 2021·Journal of Crohn's & Colitis·Roger SuauJosep Manyé
Nov 2, 2021·Frontiers in Oncology·Yang YuHao Chen
Dec 18, 2021·Clinical Science·Nikita LadPhilip G McTernan

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