The Role of Adipokines and Bone Marrow Adipocytes in Breast Cancer Bone Metastasis.

International Journal of Molecular Sciences
Eunah Shin, Ja Seung Koo

Abstract

The morbidity and mortality of breast cancer is mostly due to a distant metastasis, especially to the bone. Many factors may be responsible for bone metastasis in breast cancer, but interactions between tumor cells and other surrounding types of cells, and cytokines secreted by both, are expected to play the most important role. Bone marrow adipocyte (BMA) is one of the cell types comprising the bone, and adipokine is one of the cytokines secreted by both breast cancer cells and BMAs. These BMAs and adipokines are known to be responsible for cancer progression, and this review is focused on how BMAs and adipokines work in the process of breast cancer bone metastasis. Their potential as suppressive targets for bone metastasis is also explored in this review.

References

Oct 1, 1989·The American Journal of Physiology·A GéloënL J Bukowiecki
Apr 9, 2002·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Eric Vandeweyer, Dina Hertens
Jul 5, 2003·Cancer Cell·Yibin KangJoan Massagué
Aug 15, 2003·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M HarvieA H Howell
Nov 6, 2003·Clinical & Experimental Metastasis·Erin D Giles, Gurmit Singh
Oct 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Cecilia GarofaloEva Surmacz
May 25, 2005·The Journal of Cell Biology·Sunyoung LeeM Luisa Iruela-Arispe
Jun 18, 2005·Journal of Anatomy·D T RamsayP E Hartmann
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yibin KangJoan Massagué
Sep 30, 2005·The American Journal of Pathology·Robert J WeilPatricia S Steeg
May 9, 2006·Biochemical and Biophysical Research Communications·Marie-Noelle DieudonneRené Pecquery
Jun 14, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ahmed BoucharabaOlivier Peyruchaud
Jan 11, 2007·Oncogene·B SinghA Lucci
Aug 29, 2007·Immunology and Cell Biology·Heike Knüpfer, Rainer Preiss
Oct 19, 2007·Cancer Research·Céline Le GallPhilippe Clézardin
Oct 30, 2007·Clinical & Experimental Metastasis·Zhigang LiMing Zhang
Nov 3, 2007·Experimental Cell Research·Michelle KinderAndrea M Mastro
Jan 10, 2008·British Journal of Cancer·M E GrossmannM P Cleary
Feb 5, 2008·Biochemical and Biophysical Research Communications·Haiping JiangShaoqing Chen
Apr 15, 2008·Experimental Biology and Medicine·Candida N PereraIgnacio G Camarillo
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Celina G KleerKornelia Polyak
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Jun 9, 2009·Experimental Gerontology·Marco GasparriniGustavo Duque
Jul 25, 2009·Clinical & Experimental Metastasis·Munehisa TakahashiTomoko Okada
Aug 25, 2009·The American Journal of Pathology·Izabela PodgorskiBonnie F Sloane
Apr 27, 2010·Cell Adhesion & Migration·Neeraj K Saxena, Dipali Sharma
May 21, 2010·Arquivos brasileiros de endocrinologia e metabologia·Francisco J A de Paula, Clifford J Rosen

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Marie-Therese HaiderHanna Taipaleenmäki
Jun 3, 2021·International Journal of Molecular Sciences·Andy GöbelTilman D Rachner

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