The role of adipokines as prognostic factors of one-year mortality in hip fracture patients

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
T GulinM Borojević

Abstract

This study investigated the impact of anthropometric parameters, adiponectin, leptin, homeostatic model assessment for insulin resistance (HOMA-IR), beta-isomerised C-terminal telopeptide of collagen type I (β-CTX), and routine biochemical tests on one-year mortality in hip fracture patients. We found that male patients with high adiponectin, leptin, and β-CTX levels had a 5-fold increase in all-cause one-year mortality. Several predictors of one-year hip fracture mortality have been identified including advanced age, male sex, low bone mineral density, and preexisting comorbidities. However, the impact of metabolic parameters on hip fracture mortality remains unknown. The aim of this study was to examine the effect of serum leptin and adiponectin levels, as well as other metabolic parameters on all-cause one-year hip fracture mortality. This prospective study included 236 patients of all ages with non-traumatic hip fractures. Anthropometric parameters, adiponectin, leptin, HOMA-IR, β-CTX, and routine biochemical tests were recorded at admission and correlated with one-year mortality by using multivariate Cox proportional hazard models. The median patient age was 82 (75-87) years, and one-year mortality rate was 28.4%. In univa...Continue Reading

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Citations

Jul 28, 2018·The Journal of Clinical Endocrinology and Metabolism·Thach TranJacqueline R Center
Nov 6, 2018·The Journal of Clinical Endocrinology and Metabolism·Maria Giovanna ScaraleClaudia Menzaghi
Dec 22, 2017·Diabetes·Claudia Menzaghi, Vincenzo Trischitta
Nov 28, 2019·BioMed Research International·Qian-Hao YangYou-Shui Gao
Mar 29, 2019·World Journal of Orthopedics·Colum DowneyJohn F Quinlan

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