The role of adipokines in systemic sclerosis: a missing link?

Archives of Dermatological Research
Jakub ŻółkiewiczLidia Rudnicka

Abstract

Systemic sclerosis is a multiorgan autoimmune disease characterized by vasculopathy and tissue fibrosis of unknown etiology. Recently, adipokines (cell signaling proteins secreted by adipose tissue) have attracted much attention as a cytokine family contributing to the various pathological processes of systemic sclerosis. Adipokines, such as leptin, adiponectin, resistin, adipsin, visfatin or chemerin are a heterogenic group of molecules. Adiponectin exhibits anti-fibrotic features and affects inflammatory reactions. Leptin promotes fibrosis and inflammation. Resistin was linked to vascular involvement in systemic sclerosis. Visfatin was associated with regression of skin lesions in late-stage systemic sclerosis. Chemerin appears as a marker of increased risk of impaired renal function and development of skin sclerosis in the early stage of systemic sclerosis. Vaspin was indicated to have a protective role in digital ulcers development. Novel adipokines-adipsin, apelin, omentin and CTRP-3-are emerging as molecules potentially involved in SSc pathogenesis. Serum adipokine levels may be used as predictive and diagnostic factors in systemic sclerosis. However, further investigations are required to establish firm correlations betw...Continue Reading

References

Jan 1, 1972·Archives of Dermatology·R FleischmajerA Nedwich
Sep 1, 1996·The Journal of Clinical Endocrinology and Metabolism·M RosenbaumR L Leibel
May 8, 1997·Nature·F ZhangR W Schevitz
Feb 17, 2000·Cellular Immunology·C Martín-RomeroV Sánchez-Margalet
Dec 31, 2002·Biochemical and Biophysical Research Communications·Lisa PatelStephen A Smith
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Erin E Kershaw, Jeffrey S Flier
Aug 3, 2004·Nature Reviews. Immunology·Thomas A Wynn
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria BokarewaAndrej Tarkowski
Jul 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Kazuyuki HidaYashpal S Kanwar
Dec 6, 2005·FEBS Letters·Noboru YamaguchiYoshihisa Yamashita
Jan 26, 2006·Journal of Leukocyte Biology·Markus NeumeierChrista Buechler
Feb 20, 2007·Immunity·Veronica De RosaGiuseppe Matarese
Aug 7, 2007·Biochemical and Biophysical Research Communications·Franziska SchoberChrista Buechler
Aug 19, 2007·Endocrinology·Fred Haugen, Christian A Drevon
Jan 9, 2008·Biochemical and Biophysical Research Communications·Philip W PeakeJohn A Charlesworth
Dec 31, 2008·The Journal of Experimental Medicine·Cristina AlbanesiSilvano Sozzani
Jul 16, 2009·Experimental Dermatology·Burkhard PoeggelerRalf Paus
Sep 3, 2009·Molecular and Cellular Endocrinology·Sandra GalicGregory R Steinberg
Sep 17, 2009·Journal of Cellular and Molecular Medicine·Andrej TarkowskiMaria I Bokarewa
Nov 6, 2009·Journal of Physiology and Biochemistry·T Handjieva-Darlenska, N Boyadjieva
Dec 24, 2009·The Journal of Biological Chemistry·Koji OhashiKenneth Walsh
Feb 24, 2010·The Journal of Experimental Medicine·Mark S WilsonThomas A Wynn
Feb 26, 2010·PPAR Research·Anna LeonardiniFrancesco Giorgino
Jul 9, 2010·The FEBS Journal·Thérèse Hèrvée MayiGiulia Chinetti-Gbaguidi
Nov 12, 2010·Annals of the Rheumatic Diseases·Giuseppina FarinaRobert Lafyatis
Dec 18, 2010·Clinical Rheumatology·Metin OzgenAhmet Isik
Oct 6, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S A KanzlerM A Paschoalini
Nov 1, 2011·Experimental and Molecular Pathology·Kristina EisingerKlaus W Frommer
Nov 25, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·N AozasaS Sato
Feb 22, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mi Young JungTae Sung Kim
Mar 1, 2012·The European Respiratory Journal·Alice HuertasMarc Humbert

❮ Previous
Next ❯

Citations

Nov 2, 2019·Archives of Dermatological Research·Anna StochmalLidia Rudnicka
Aug 23, 2020·International Journal of Molecular Sciences·Toshiyuki Yamamoto
Oct 20, 2020·Nephrology·Dan ZhaoXiaoxia Zhao
Jan 13, 2021·Archives of Dermatological Research·Anna StochmalLidia Rudnicka
Apr 6, 2020·The Journal of Investigative Dermatology·Janan MohamadEli Sprecher
Apr 12, 2021·Clinical Rheumatology·Antonietta GiganteEdoardo Rosato
May 14, 2021·International Journal of Immunopathology and Pharmacology·Liberato GiardulloFrancesco Paolo Cantatore
Aug 7, 2021·Clinical and Experimental Immunology·Florenzo IannoneFabio Cacciapaglia
Sep 1, 2021·Clinical and Experimental Medicine·Chiara PellicanoEdoardo Rosato
Aug 31, 2021·The International Journal of Biochemistry & Cell Biology·Chuin Ying UngTanya J Shaw
Oct 26, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A S OzorninP P Tereshkov
Jun 11, 2020·Kidney & Blood Pressure Research·Magdalena ChrabaszczLidia Rudnicka
Jul 7, 2021·Scientific Reports·Anna StochmalLidia Rudnicka

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Mediators of Inflammation
Zhaoxia Wang, Tomohiro Nakayama
Canadian Journal of Physiology and Pharmacology
Josette M NorthcottJeffrey T Wigle
Clinical and Experimental Rheumatology
Karolina Sawicka, Dorota Krasowska
© 2022 Meta ULC. All rights reserved